CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001974
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vimentin 
Protein Synonyms/Alias
  
Gene Name
 VIM 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mesocricetus auratus (Golden hamster) 
NCBI Taxa ID
 10036 
Lysine Modification
Position
Peptide
Type
References
167VDQLTNDKARVEVERubiquitination[1]
281QYESVAAKNLQEAEEubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
 Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. 
Sequence Annotation
 REGION 2 94 Head.
 REGION 95 406 Rod.
 REGION 95 130 Coil 1A.
 REGION 131 152 Linker 1.
 REGION 153 244 Coil 1B.
 REGION 245 267 Linker 12.
 REGION 268 406 Coil 2.
 REGION 407 465 Tail.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 5 5 Phosphoserine (By similarity).
 MOD_RES 7 7 Phosphoserine; by PKA and PKC (By
 MOD_RES 8 8 Phosphoserine (By similarity).
 MOD_RES 9 9 Phosphoserine; by PKC (By similarity).
 MOD_RES 10 10 Phosphoserine; by PKC (By similarity).
 MOD_RES 20 20 Phosphothreonine (By similarity).
 MOD_RES 21 21 Phosphoserine; by PKC (By similarity).
 MOD_RES 25 25 Phosphoserine; by PKA and PKC (By
 MOD_RES 26 26 Phosphoserine; by PKC (By similarity).
 MOD_RES 29 29 Phosphoserine (By similarity).
 MOD_RES 33 33 Phosphothreonine (By similarity).
 MOD_RES 34 34 Phosphoserine; by PKC (By similarity).
 MOD_RES 38 38 Phosphotyrosine (By similarity).
 MOD_RES 39 39 Phosphoserine; by CaMK2, PKA, PKC and
 MOD_RES 42 42 Phosphoserine; by PKC (By similarity).
 MOD_RES 46 46 Phosphoserine; by PKA (By similarity).
 MOD_RES 48 48 Phosphoserine (By similarity).
 MOD_RES 50 50 Phosphoserine; by PKA and PKC (By
 MOD_RES 52 52 Phosphotyrosine (By similarity).
 MOD_RES 54 54 Phosphoserine (By similarity).
 MOD_RES 55 55 Phosphoserine; by CDK5 and CDK1.
 MOD_RES 60 60 Phosphotyrosine (By similarity).
 MOD_RES 65 65 Phosphoserine (By similarity).
 MOD_RES 71 71 Phosphoserine; by AURKB and ROCK2 (By
 MOD_RES 72 72 Phosphoserine (By similarity).
 MOD_RES 82 82 Phosphoserine (By similarity).
 MOD_RES 103 103 N6-acetyllysine (By similarity).
 MOD_RES 116 116 Phosphotyrosine (By similarity).
 MOD_RES 119 119 N6-acetyllysine (By similarity).
 MOD_RES 138 138 N6-acetyllysine (By similarity).
 MOD_RES 143 143 Phosphoserine (By similarity).
 MOD_RES 213 213 Phosphoserine (By similarity).
 MOD_RES 225 225 Phosphoserine (By similarity).
 MOD_RES 260 260 Phosphoserine (By similarity).
 MOD_RES 265 265 Phosphothreonine (By similarity).
 MOD_RES 291 291 N6-acetyllysine (By similarity).
 MOD_RES 298 298 Phosphoserine (By similarity).
 MOD_RES 372 372 N6-acetyllysine (By similarity).
 MOD_RES 401 401 N6-acetyllysine (By similarity).
 MOD_RES 408 408 Phosphoserine (By similarity).
 MOD_RES 411 411 Phosphoserine (By similarity).
 MOD_RES 418 418 Phosphoserine (By similarity).
 MOD_RES 419 419 Phosphoserine (By similarity).
 MOD_RES 425 425 Phosphothreonine (By similarity).
 MOD_RES 429 429 Phosphoserine (By similarity).
 MOD_RES 435 435 Phosphothreonine (By similarity).
 MOD_RES 444 444 N6-acetyllysine (By similarity).
 MOD_RES 445 445 Phosphothreonine (By similarity).
 MOD_RES 457 457 Phosphothreonine (By similarity).
 MOD_RES 458 458 Phosphoserine (By similarity).  
Keyword
 Acetylation; Coiled coil; Cytoplasm; Intermediate filament; Phosphoprotein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 465 AA 
Protein Sequence
MSTRSVSSSS YRRMFGGPGT SNRQSSNRSY VTTSTRTYSL GSLRPSTSRS LYSSSPGGAY 60
VTRSSAVRLR SSMPGVRLLQ DSVDFSLADA INTEFKNTRT NEKVELQELN DRFANYIDKV 120
RFLEQQNKIL LAELEQLKGQ GKSRLGDLYE EEMRELRRQV DQLTNDKARV EVERDNLAED 180
IMRLREKLQE EMLQREEAES TLQSFRQDVD NASLARLDLE RKVESLQEEI AFLKKLHDEE 240
IQELQAQIQE QHVQIDVDVS KPDLTAALRD VRQQYESVAA KNLQEAEEWY KSKFADLSEA 300
ANRNNDALRQ AKQESNEYRR QVQSLTCEVD ALKGTNESLE RQMREMEENF ALEAANYQDT 360
IGRLQDEIQN MKEEMARHLR EYQDLLNVKM ALDIEIATYR KLLEGEESRI SLPLPNFSSL 420
NLRETNLESL PLVDTHSKRT LLIKTVETRD GQVINETSQH HDDLE 465 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005882; C:intermediate filament; ISS:UniProtKB.
 GO:0005200; F:structural constituent of cytoskeleton; ISS:UniProtKB. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR006821; Intermed_filament_DNA-bd.
 IPR018039; Intermediate_filament_CS. 
Pfam
 PF00038; Filament
 PF04732; Filament_head 
SMART
  
PROSITE
 PS00226; IF 
PRINTS