UniProt Accession

 BL1S5_HUMAN; Q8TDH9; B4DVM2; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q9NU16 

Genbank Protein ID

 AF426434; AK301142; CR749569; AL096800; AL023694; AL023694; AL096800; BC032438; BC119644; BC119645 

Genbank Nucleotide ID

 AAL99385.1; BAG62734.1; CAH18364.1; CAI20106.1; CAI20106.1; CAI21645.1; CAI21645.1; AAH32438.1; AAI19645.1; AAI19646.1 

Protein Name

 Biogenesis of lysosome-related organelles complex 1 subunit 5 

Protein Synonyms/Alias

 BLOC-1 subunit 5; Protein Muted homolog 

Gene Name

 BLOC1S5 

Gene Synonyms/Alias

 MUTED 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
37	GSAHLIIKDLGEIHS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 187 AA 

Protein Sequence

Gene Ontology

 GO:0031083; C:BLOC-1 complex; IDA:UniProtKB.
 GO:0030133; C:transport vesicle; IDA:UniProtKB.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
 GO:0035646; P:endosome to melanosome transport; IDA:UniProtKB.
 GO:0032438; P:melanosome organization; NAS:UniProtKB.
 GO:0032402; P:melanosome transport; IDA:UniProtKB.
 GO:0031175; P:neuron projection development; ISS:UniProtKB.
 GO:0050942; P:positive regulation of pigment cell differentiation; IDA:UniProtKB. 

Interpro

 IPR017243; BLOC-1_complex_muted_subunit. 

Pfam

  

SMART

  

PROSITE

  

PRINTS