CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004256
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bile pigment transporter 1 
Protein Synonyms/Alias
  
Gene Name
 BPT1 
Gene Synonyms/Alias
 YLL015W; L1313 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
753CQLLPDLKILPDGDEubiquitination[1]
1418AVEQAHLKPHLEKMLubiquitination[2]
1539REFDSPSKLLSDKTSubiquitination[3, 4]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway.
 Mayor T, Graumann J, Bryan J, MacCoss MJ, Deshaies RJ.
 Mol Cell Proteomics. 2007 Nov;6(11):1885-95. [PMID: 17644757]
 [4] Systematic approach for validating the ubiquitinated proteome.
 Seyfried NT, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J.
 Anal Chem. 2008 Jun 1;80(11):4161-9. [PMID: 18433149] 
Functional Description
 Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates. 
Sequence Annotation
 DOMAIN 292 578 ABC transmembrane type-1 1.
 DOMAIN 639 871 ABC transporter 1.
 DOMAIN 980 1265 ABC transmembrane type-1 2.
 DOMAIN 1302 1553 ABC transporter 2.
 NP_BIND 672 679 ATP 1 (Potential).
 NP_BIND 1336 1343 ATP 2 (Potential).
 MOD_RES 645 645 Phosphoserine.
 MOD_RES 885 885 Phosphoserine.
 MOD_RES 889 889 Phosphothreonine.
 MOD_RES 893 893 Phosphoserine.
 MOD_RES 895 895 Phosphoserine.
 MOD_RES 916 916 Phosphothreonine.
 MOD_RES 927 927 Phosphoserine.
 MOD_RES 931 931 Phosphoserine.
 MOD_RES 934 934 Phosphothreonine.
 CARBOHYD 1011 1011 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Vacuole. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1559 AA 
Protein Sequence
MSSLEVVDGC PYGYRPYPDS GTNALNPCFI SVISAWQAVF FLLIGSYQLW KLYKNNKVPP 60
RFKNFPTLPS KINSRHLTHL TNVCFQSTLI ICELALVSQS SDRVYPFILK KALYLNLLFN 120
LGISLPTQYL AYFKSTFSMG NQLFYYMFQI LLQLFLILQR YYHGSSNERL TVISGQTAMI 180
LEVLLLFNSV AIFIYDLCIF EPINELSEYY KKNGWYPPVH VLSYITFIWM NKLIVETYRN 240
KKIKDPNQLP LPPVDLNIKS ISKEFKANWE LEKWLNRNSL WRAIWKSFGR TISVAMLYET 300
TSDLLSVVQP QFLRIFIDGL NPETSSKYPP LNGVFIALTL FVISVVSVFL TNQFYIGIFE 360
AGLGIRGSLA SLVYQKSLRL TLAERNEKST GDILNLMSVD VLRIQRFFEN AQTIIGAPIQ 420
IIVVLTSLYW LLGKAVIGGL VTMAIMMPIN AFLSRKVKKL SKTQMKYKDM RIKTITELLN 480
AIKSIKLYAW EEPMMARLNH VRNDMELKNF RKIGIVSNLI YFAWNCVPLM VTCSTFGLFS 540
LFSDSPLSPA IVFPSLSLFN ILNSAIYSVP SMINTIIETS VSMERLKSFL LSDEIDDSFI 600
ERIDPSADER ALPAIEMNNI TFLWKSKEVL TSSQSGDNLR TDEESIIGSS QIALKNIDHF 660
EAKRGDLVCV VGRVGAGKST FLKAILGQLP CMSGSRDSIP PKLIIRSSSV AYCSQESWIM 720
NASVRENILF GHKFDQDYYD LTIKACQLLP DLKILPDGDE TLVGEKGISL SGGQKARLSL 780
ARAVYSRADI YLLDDILSAV DAEVSKNIIE YVLIGKTALL KNKTIILTTN TVSILKHSQM 840
IYALENGEIV EQGNYEDVMN RKNNTSKLKK LLEEFDSPID NGNESDVQTE HRSESEVDEP 900
LQLKVTESET EDEVVTESEL ELIKANSRRA SLATLRPRPF VGAQLDSVKK TAQKAEKTEV 960
GRVKTKIYLA YIKACGVLGV VLFFLFMILT RVFDLAENFW LKYWSESNEK NGSNERVWMF 1020
VGVYSLIGVA SAAFNNLRSI MMLLYCSIRG SKKLHESMAK SVIRSPMTFF ETTPVGRIIN 1080
RFSSDMDAVD SNLQYIFSFF FKSILTYLVT VILVGYNMPW FLVFNMFLVV IYIYYQTFYI 1140
VLSRELKRLI SISYSPIMSL MSESLNGYSI IDAYDHFERF IYLNYEKIQY NVDFVFNFRS 1200
TNRWLSVRLQ TIGATIVLAT AILALATMNT KRQLSSGMVG LLMSYSLEVT GSLTWIVRTT 1260
VTIETNIVSV ERIVEYCELP PEAQSINPEK RPDENWPSKG GIEFKNYSTK YRENLDPVLN 1320
NINVKIEPCE KVGIVGRTGA GKSTLSLALF RILEPTEGKI IIDGIDISDI GLFDLRSHLA 1380
IIPQDAQAFE GTVKTNLDPF NRYSEDELKR AVEQAHLKPH LEKMLHSKPR GDDSNEEDGN 1440
VNDILDVKIN ENGSNLSVGQ RQLLCLARAL LNRSKILVLD EATASVDMET DKIIQDTIRR 1500
EFKDRTILTI AHRIDTVLDS DKIIVLDQGS VREFDSPSKL LSDKTSIFYS LCEKGGYLK 1559 
Gene Ontology
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0015127; F:bilirubin transmembrane transporter activity; IMP:SGD.
 GO:0015086; F:cadmium ion transmembrane transporter activity; IDA:SGD.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0042144; P:vacuole fusion, non-autophagic; IMP:SGD. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS