| Tag | Content |
|---|
| CPLM ID | CPLM-022368 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Voltage-dependent calcium channel subunit alpha-2/delta-2 |
Protein Synonyms/Alias | Voltage-gated calcium channel subunit alpha-2/delta-2; Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2 |
Gene Name | CACNA2D2 |
Gene Synonyms/Alias | KIAA0558 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 413 | RVQDVFEKYNWPNRT | ubiquitination | [1] | | 478 | RPMVLAGKEAKQVQW | ubiquitination | [1] | | 611 | KQIRTLVKSLDERYI | ubiquitination | [1] | | 686 | IAPREYCKDLNASDN | ubiquitination | [1] | | 699 | DNNTEFLKNFIELME | ubiquitination | [1] | | 707 | NFIELMEKVTPDSKQ | ubiquitination | [1] | | 766 | ITRVFPNKAAEDWTE | ubiquitination | [1] | | 847 | DLEAWAEKFKVLASN | ubiquitination | [1] | | 928 | NNSFYTRKESYDYQA | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. |
Sequence Annotation | DOMAIN 291 469 VWFA.
DOMAIN 485 574 Cache.
MOTIF 297 301 MIDAS-like motif.
METAL 297 297 Divalent metal cation (By similarity).
METAL 299 299 Divalent metal cation (By similarity).
METAL 301 301 Divalent metal cation (By similarity).
CARBOHYD 386 386 N-linked (GlcNAc...).
CARBOHYD 418 418 N-linked (GlcNAc...) (Potential).
CARBOHYD 507 507 N-linked (GlcNAc...) (Potential).
CARBOHYD 540 540 N-linked (GlcNAc...) (Potential).
CARBOHYD 861 861 N-linked (GlcNAc...) (Potential).
DISULFID 443 1098 Interchain (between alpha-2-2 and delta-2 |
Keyword | Alternative splicing; Calcium; Calcium channel; Calcium transport; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Membrane; Metal-binding; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1150 AA |
Protein Sequence | MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL LPLLAAPGAS 60
AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD NRNLFEVQEN EPQKLVEKVA 120
GDIESLLDRK VQALKRLADA AENFQKAHRW QDNIKEEDIV YYDAKADAEL DDPESEDVER 180
GSKASTLRLD FIEDPNFKNK VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR 240
QDPTLLWQVF GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG 300
SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV RNKKVFKEAV 360
QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT DGGEDRVQDV FEKYNWPNRT 420
VRVFTFSVGQ HNYDVTPLQW MACANKGYYF EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA 480
KQVQWTNVYE DALGLGLVVT GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN 540
YTLGANGYVF AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN 600
KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ ANLSDQILQV 660
KYFEFLLPSS FESEGHVFIA PREYCKDLNA SDNNTEFLKN FIELMEKVTP DSKQCNNFLL 720
HNLILDTGIT QQLVERVWRD QDLNTYSLLA VFAATDGGIT RVFPNKAAED WTENPEPFNA 780
SFYRRSLDNH GYVFKPPHQD ALLRPLELEN DTVGILVSTA VELSLGRRTL RPAVVGVKLD 840
LEAWAEKFKV LASNRTHQDQ PQKCGPNSHC EMDCEVNNED LLCVLIDDGG FLVLSNQNHQ 900
WDQVGRFFSE VDANLMLALY NNSFYTRKES YDYQAACAPQ PPGNLGAAPR GVFVPTVADF 960
LNLAWWTSAA AWSLFQQLLY GLIYHSWFQA DPAEAEGSPE TRESSCVMKQ TQYYFGSVNA 1020
SYNAIIDCGN CSRLFHAQRL TNTNLLFVVA EKPLCSQCEA GRLLQKETHS DGPEQCELVQ 1080
RPRYRRGPHI CFDYNATEDT SDCGRGASFP PSLGVLVSLQ LLLLLGLPPR PQPQVLVHAS 1140
RRL 1143 |
Gene Ontology | GO:0005886; C:plasma membrane; TAS:Reactome. GO:0005891; C:voltage-gated calcium channel complex; IEA:Compara. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005245; F:voltage-gated calcium channel activity; IEA:Compara. GO:0006112; P:energy reserve metabolic process; TAS:Reactome. GO:0007528; P:neuromuscular junction development; IEA:Compara. GO:0046622; P:positive regulation of organ growth; IEA:Compara. GO:0050796; P:regulation of insulin secretion; TAS:Reactome. GO:0040014; P:regulation of multicellular organism growth; IEA:Compara. GO:0060024; P:rhythmic synaptic transmission; IEA:Compara. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
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