UniProt Accession

 E9Q489_MOUSE; E9Q489 

Genbank Protein ID

 AC074310 

Genbank Nucleotide ID

  

Protein Name

 Calsequestrin 

Protein Synonyms/Alias

  

Gene Name

 Casq1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
55	RVINVNAKNYKNVFK	ubiquitination	[1]
63	NYKNVFKKYEVLALL	acetylation	[2]
79	HEPPEDDKASQRQFE	ubiquitination	[1]
125	IKLIGYFKSKDSEHY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction (By similarity). 

Sequence Annotation

  

Keyword

 Calcium; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 156 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0033018; C:sarcoplasmic reticulum lumen; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007029; P:endoplasmic reticulum organization; IMP:MGI.
 GO:0014809; P:regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; IMP:MGI.
 GO:0009408; P:response to heat; IMP:MGI. 

Interpro

 IPR001393; Calsequestrin.
 IPR018233; Calsequestrin_CS.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF01216; Calsequestrin 

SMART

  

PROSITE

 PS00863; CALSEQUESTRIN_1 

PRINTS

 PR00312; CALSEQUESTRN.