CPLM-000842

Genbank Nucleotide ID

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
83	DSHSFGEKNSTLSEE	ubiquitination	[1]
104	REVESILKKNSDWIW	ubiquitination	[1]
146	RNTSVMKKGGIFSAD	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity).

MOTIF 93 118 BH3.
MOD_RES 79 79 Phosphoserine.
MOD_RES 85 85 Phosphoserine.
MOD_RES 86 86 Phosphothreonine.
MOD_RES 88 88 Phosphoserine.
MOD_RES 92 92 Phosphotyrosine.

Apoptosis; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030425; C:dendrite; ISS:UniProtKB.
GO:0031307; C:integral to mitochondrial outer membrane; ISS:UniProtKB.
GO:0005635; C:nuclear envelope; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0042803; F:protein homodimerization activity; IDA:MGI.
GO:0006309; P:apoptotic DNA fragmentation; ISS:UniProtKB.
GO:0048102; P:autophagic cell death; IEA:Compara.
GO:0050873; P:brown fat cell differentiation; IDA:MGI.
GO:0071279; P:cellular response to cobalt ion; IEA:Compara.
GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
GO:0071456; P:cellular response to hypoxia; IEA:Compara.
GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
GO:0006338; P:chromatin remodeling; ISS:UniProtKB.
GO:0051607; P:defense response to virus; ISS:UniProtKB.
GO:0006917; P:induction of apoptosis; ISS:UniProtKB.
GO:0097193; P:intrinsic apoptotic signaling pathway; IMP:MGI.
GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IEA:Compara.
GO:0097345; P:mitochondrial outer membrane permeabilization; ISS:UniProtKB.
GO:0035694; P:mitochondrial protein catabolic process; ISS:UniProtKB.
GO:0045837; P:negative regulation of membrane potential; ISS:UniProtKB.
GO:0010637; P:negative regulation of mitochondrial fusion; IEA:Compara.
GO:0051402; P:neuron apoptotic process; ISS:UniProtKB.
GO:0090141; P:positive regulation of mitochondrial fission; IEA:Compara.
GO:0043243; P:positive regulation of protein complex disassembly; IEA:Compara.
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Compara.
GO:0072593; P:reactive oxygen species metabolic process; ISS:UniProtKB.
GO:0055093; P:response to hyperoxia; IEA:Compara.
GO:0001666; P:response to hypoxia; ISS:UniProtKB.