CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038426
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Nbas 
Protein Synonyms/Alias
  
Gene Name
 Nbas 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
114CVEIRSAKDDFTSIIubiquitination[1]
672LKLVNFSKLTLEQKEubiquitination[1]
686ELCRCRLKLLTFLDRubiquitination[1]
1056LKTHGLEKPVSFVKNacetylation[2]
1437SDGQWWKKSLAYLRPubiquitination[1]
1588PLYRVDPKELIKMVTubiquitination[1]
1916TIKHFIEKPRKRNSEacetylation[3, 4]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2356 AA 
Protein Sequence
MAAPESAPAL SPGSADEEET ILYDLLVNTE WPPETEVQLR GNRKHGASFI ITKAIRDHLL 60
FLRQYIWYSP APFLLPDGLV RLVNKQINWH LVLANNGKLL AAVQDQCVEI RSAKDDFTSI 120
IGKCQVPKDP KPQWRRVAWS YDCTLLAYAE STGTVRVFDL MGSELFVIAP ASVFAGDLSY 180
AIAGLVFLEY KASAQWSAEL LVINYRGELR SYLVSVGTNQ SYQESHSFSF SGHYPHGINT 240
AIYHPGHRLL LVGGCETAEL GISKAASCGL SAWRVLSGSP YYKQVTNGGD RVTEVPKTLG 300
LLKLLSVKLS PRLGQEQDGI FKMGLSPDGS LLAAIHFSGK LSIWAIPSLK QQGVWRQDEQ 360
PGYNELNPDW RLSPEKRKKV KDKESFYPLI DVNWWADGAV TLARCSGALT VSSAKSLKNL 420
LGKSCEWFEP SPQVTATHDG GFLSLECEIK LAPKRSRVEM RAGEEDEGEV DSDSDPETSA 480
KARYFGYIKQ GLYLVTEMER FAPPRKRPRT ITKNYRLVSL RSTTPEELYQ RKIDSEDYEE 540
ALCLAHTYGL DTDLVYQRQW RKSAVNSASI HNYLSKIKKR SWVLHECLER VPENVDAAKE 600
LLQYGLKGTD LEALVAIGKG VDDGRFTLPG DIDIDSIAYE ELSPADKEPS KSKRQEELKK 660
RRDLLKLVNF SKLTLEQKEL CRCRLKLLTF LDRLATYEEI LGAPHASEQR YDAEFFKKFR 720
SQNIVLSART YARESNVQAL EILLTYHGSH LLPHRLAILS NFPETTSPHE YAVLLPEACW 780
NNDSLTIIPW AEHKHRAEDW CEELECRMVV EPSLQDDSEF LYAAQPELLQ YRTPQLTVEK 840
VMAWYQSRAE DIEHHAGQVD CALSLVRLGV ERHIPGLLTL CDDLVTLETL VYEAGCDFTL 900
TLKDLQQMKD FEKLRLLMEH CSEDNYVTSA YQWMVPFLHR CEKQSPGAAN ELLREYLVTL 960
AKGDLKLPLK IFQHSKPDLQ QKIIPDEDQL MAIALECIYN CERSDQLSLC YDILECLPQR 1020
GCGHNTKVTS SLHDMVDQLE KILSVSELLK THGLEKPVSF VKNTQSSSEE ARSLMVRLTR 1080
HTGRKQPSVG ESHWRMLLQD MLTMQQHVYT CLDSSACYEI FTESLLCSSR LENIHLAGQM 1140
MQCSACLDNP PAGALHKGRA QYRVSYERSI DLVLAASREY FNSSTNLTDS CMDLARCCLQ 1200
LITDRPAAIQ EELDLIQALG YLEEFGVKTL PLQVRLCSDR ISLIKECVSQ SPTCYKQSAK 1260
LLGLAELLRV AGEDPEGRRG QVLILLVEQA LHVHDYKVAS MYCQQLMAAG YPESWAVCSQ 1320
LGQSEGYQDL ATRQELMAFA LTHCPPSSIE LLLEASSSLQ TEILYQRVNF EIHPEGENIS 1380
ASPLPVKVLQ EDAAALGSSS ADLLHWTTAT TMKVLSNTTT TTKAVLQAVS DGQWWKKSLA 1440
YLRPYQGQEF GRAYRIGIVA NDDLERQGCH PFYESVIANP FVTEVPVESF AEVLLRTGKL 1500
TEAQTQVFPT TEVLLQLASD ALPNDMTLAL AYLLALPQVL DANKCFEKQA HSALSLQLAA 1560
YYYSLQIYAR LAPCFRDKCH PLYRVDPKEL IKMVTGHVAQ HGHEGWPEDL LSLSRQLHYY 1620
SERLLDFTQA QLLQGLRKGV DVQRFTADDQ YKRETILGLA ESLEENVYSI ALSLAQRYSI 1680
SQWEVFMTHL EFLFSESGLS TGEIEKRAQT LHLFDTLKTD PESFHKHMVK YIYPTIEGLD 1740
HERLLYYFTL LESCGCANFE TTAIKPEIHI RLLKKFKVVA SGLNYKKLTD KSEDALEALE 1800
PVLTSQNILS ISKLAPRIPG KHGQMLSPSS LYTVWLQKLF WAGDPHLIKQ APESSAEWLH 1860
ACDVCLKYFD RLCPDDLITV MDAITFSPKA VSKLSVEARE EMTRKAIKTI KHFIEKPRKR 1920
NSEEDPQEGR GSQATYPDAL AHLETSLAHL ETLSHSFILS LRNSEQEILQ KYSYFYDLSR 1980
SEKEKIHDQA VAMCLDGQPL RMIQQLLEVA IGPVNISPKD IVHTAITQII SALSGGSADL 2040
CGSRDPLQVL EGVVGAVRTS VDNGEELVSA EDVLQWLRPF CAEDTYPVRP RIQVLQLLGQ 2100
SFHLSEEDGK LLVFFRTEAI LRAAWPQRQV DIADIENEEN RHTLFSELLE SSHREVEFQH 2160
LILLLQAWPP MKSECVLANN PWVRLVTAML TRCTEENKQS LGDEVLKICR SLYNTTQMLP 2220
VEGVKELCLL LLHQSLLLPS LKLLLESGEE SLQAMALEQI SAVTKVNDSN CDQELLSLLV 2280
DARLLVKCVS TPFYPHIVGH LVANNQQGRW NIEELARHLQ EAGHEVEAGS LLLAVQGTHR 2340
VFRTFSIALS AVRQWV 2356 
Gene Ontology
  
Interpro
 IPR011044; Quino_amine_DH_bsu.
 IPR013244; Sec39.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF08314; Sec39 
SMART
  
PROSITE
  
PRINTS