UniProt Accession

 COF1A_XENLA; P45695; Q5D0B5 

Genbank Protein ID

 U26270; BC044691 

Genbank Nucleotide ID

 AAB00540.1; AAH44691.1 

Protein Name

 Cofilin-1-A 

Protein Synonyms/Alias

 ADF/cofilin-1; XAC1 

Gene Name

 cfl1-a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Xenopus laevis (African clawed frog) 

NCBI Taxa ID

 8355 

Lysine Modification

Position	Peptide	Type	References
73	DPYKTFVKMLPRNDC	acetylation	[1]
92	YDALYETKETKKEDL	acetylation	[1]

Reference

 [1] A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2.
 Andersen JL, Thompson JW, Lindblom KR, Johnson ES, Yang CS, Lilley LR, Freel CD, Moseley MA, Kornbluth S.
 Mol Cell. 2011 Sep 2;43(5):834-42. [PMID: 21884983] 

Functional Description

 May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Required for formation of the cleavage furrow during cytokinesis. 

Sequence Annotation

 DOMAIN 4 153 ADF-H.
 MOTIF 30 34 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Actin-binding; Cytoplasm; Cytoskeleton; Membrane; Nucleus; Phosphoprotein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 168 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0005938; C:cell cortex; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0051015; F:actin filament binding; IDA:UniProtKB.
 GO:0030042; P:actin filament depolymerization; IDA:UniProtKB.
 GO:0000910; P:cytokinesis; IMP:UniProtKB.
 GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB. 

Interpro

 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR017904; ADF/Cofilin/Destrin.
 IPR027234; Cofilin_1/2. 

Pfam

 PF00241; Cofilin_ADF 

SMART

 SM00102; ADF 

PROSITE

 PS51263; ADF_H 

PRINTS

 PR00006; COFILIN.