UniProt Accession

 B1AR28_MOUSE; B1AR28 

Genbank Protein ID

 AL596185 

Genbank Nucleotide ID

  

Protein Name

 Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Acadvl 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
58	SFAVGMFKGQLTIDQ	acetylation	[1]
100	EEVNDPAKNDALEKV	acetylation	[1, 2]
100	EEVNDPAKNDALEKV	ubiquitination	[3]
106	AKNDALEKVEDDTLQ	acetylation	[1, 2, 4, 5, 6]
106	AKNDALEKVEDDTLQ	succinylation	[6]
106	AKNDALEKVEDDTLQ	ubiquitination	[3]
174	GILLYGTKAQREKYL	acetylation	[6]
174	GILLYGTKAQREKYL	succinylation	[6]
218	AIPSPCGKYYTLNGS	acetylation	[1, 5, 6, 7, 8]
218	AIPSPCGKYYTLNGS	succinylation	[6]
218	AIPSPCGKYYTLNGS	ubiquitination	[3]
247	VFAKTPIKDAATGAV	acetylation	[5, 6]
247	VFAKTPIKDAATGAV	succinylation	[6]
247	VFAKTPIKDAATGAV	ubiquitination	[3]
255	DAATGAVKEKITAFV	acetylation	[1, 5, 6, 8]
255	DAATGAVKEKITAFV	succinylation	[6]
255	DAATGAVKEKITAFV	succinylation	[6]
257	ATGAVKEKITAFVVE	acetylation	[1, 5, 6]
257	ATGAVKEKITAFVVE	succinylation	[6]
277	VTHGLPEKKMGIKAS	acetylation	[1, 5]
277	VTHGLPEKKMGIKAS	ubiquitination	[3]
295	EVYFDGVKVPSENVL	acetylation	[1, 5]
295	EVYFDGVKVPSENVL	ubiquitination	[3]
310	GEVGDGFKVAVNILN	acetylation	[4, 5, 6, 8]
310	GEVGDGFKVAVNILN	succinylation	[6]
310	GEVGDGFKVAVNILN	ubiquitination	[9]
337	TMKSLIAKAVDHATN	acetylation	[5, 7, 10]
337	TMKSLIAKAVDHATN	ubiquitination	[3]
351	NRTQFGDKIHNFGVI	acetylation	[1, 5, 6]
351	NRTQFGDKIHNFGVI	succinylation	[6]
351	NRTQFGDKIHNFGVI	ubiquitination	[3]
361	NFGVIQEKLARMAIL	acetylation	[10]
461	QGCMDKGKELTGLGN	acetylation	[5, 6]
461	QGCMDKGKELTGLGN	succinylation	[6]
486	LLMGEAGKQLRRRTG	ubiquitination	[3]
529	FATVVEAKLVKHKKG	acetylation	[5, 8]
535	AKLVKHKKGIVNEQF	acetylation	[5, 6]
535	AKLVKHKKGIVNEQF	succinylation	[6]
579	YPTAQHEKMLCDSWC	acetylation	[1]
618	RNFRSISKAMVENGG	acetylation	[1, 6]
618	RNFRSISKAMVENGG	succinylation	[6]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [5] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [7] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [8] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [9] A proteomics approach to identify the ubiquitinated proteins in mouse heart.
 Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ.
 Biochem Biophys Res Commun. 2007 Jun 8;357(3):731-6. [PMID: 17451654]
 [10] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 634 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. 

Interpro

 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 

Pfam

 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 

SMART

  

PROSITE

 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 

PRINTS