UniProt Accession

 UK114_RAT; P52759; O35262; Q9WUV8 

Genbank Protein ID

 D49363; X70825; AF015949; BC078779 

Genbank Nucleotide ID

 BAA08359.1; CAB36976.1; AAB70815.1; AAH78779.1 

Protein Name

 Ribonuclease UK114 

Protein Synonyms/Alias

 14.5 kDa translational inhibitor protein; Perchloric acid soluble protein 

Gene Name

 Hrsp12 

Gene Synonyms/Alias

 Psp1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
7	*MSSIIRKVISTSKA	acetylation	[1]
13	RKVISTSKAPAAIGA	acetylation	[1]
56	GGVAEEAKQALKNLG	acetylation	[1]
60	EEAKQALKNLGEILK	acetylation	[1]
67	KNLGEILKAAGCDFT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 21 21 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Endonuclease; Hydrolase; Mitochondrion; Nuclease; Nucleus; Peroxisome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 137 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0019239; F:deaminase activity; IEA:InterPro.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 

Interpro

 IPR013813; Endoribo_LPSP/chorism_mut-like.
 IPR006056; YjgF-like.
 IPR019897; YjgF-like_CS.
 IPR006175; YjgF/Yer057p/UK114. 

Pfam

 PF01042; Ribonuc_L-PSP 

SMART

  

PROSITE

 PS01094; UPF0076 

PRINTS