CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035067
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase transmembrane receptor 
Protein Synonyms/Alias
  
Gene Name
 Ror2 
Gene Synonyms/Alias
 Ror2_predicted; rCG_44131 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
489DRFGKVYKGHLFGPAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Kringle; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 943 AA 
Protein Sequence
MARGWVRPSR VPLCVRAVWT AAALLLWTPW TAGEVEDSEA IDTLGQLDGP DSPLPTLKGY 60
FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA PVVQEPRRVI IRKTEYGSRL 120
RIQDLDTTDT GYYQCVATNG LKTITATGVL YVRLGPTHSP NHNFQDDDQE DGFCQPYRGI 180
ACARFIGNRT IYVDSLQMQG EIENRITAAF TMIGTSTHLS DQCSQFAIPS FCHFVFPLCD 240
ARSRAPKPRE LCRDECEVLE NDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC 300
MRIGIPAERL GRYHQCYNGS GTDYRGMAST TKSGHQCQPW ALQHPHSHRL SSTEFPELGG 360
GHAYCRNPGG QMEGPWCFTQ NKNVRVELCD VPPCSPRDGS KMGILYILVP SIAIPLVIAC 420
LFFLVCMCRN KQKASASTPQ RRQLMASPSQ DMEMPLISQH KQAKLKEISL STVRFMEELG 480
EDRFGKVYKG HLFGPAPGEP TQVVAIKTLK DKAEGPLREE FRQEAMLRAR LQHPNIVCLL 540
GVVTKDQPLS MVFSYCCHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHVVAQIA 600
AGMEFLSSHH VVHKDLATRN VLVYDKLNVR ISDLGLFREV YSADYYKLMG NSLLPIRWMS 660
PEAVMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD VVEMIRSRQV LPCPDDCPAW 720
VYALMIECWN EFPSGRPRFK DIHGRLRSWG NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN 780
VSNARYMAPK QKAQPFPQPQ FIPMKGQIRP LVPPAQLYIP VNGYQPVPAY GAYLPNFYPV 840
QIPMQMAPQQ VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSVADRAALL SEGTEDVQNM 900
PEDVAQSPVQ EAEEEEEGSV PETELLGDSD TLQVNEAHVH LEA 943 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC.
 GO:0001502; P:cartilage condensation; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:Compara.
 GO:0030538; P:embryonic genitalia morphogenesis; IEA:Compara.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0007254; P:JNK cascade; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0001756; P:somitogenesis; IEA:Compara.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
 GO:0007223; P:Wnt receptor signaling pathway, calcium modulating pathway; IEA:Compara.
 GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IEA:Compara. 
Interpro
 IPR020067; Frizzled_dom.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000001; Kringle.
 IPR013806; Kringle-like.
 IPR018056; Kringle_CS.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016247; Tyr_kinase_rcpt_ROR. 
Pfam
 PF01392; Fz
 PF07679; I-set
 PF00051; Kringle
 PF07714; Pkinase_Tyr 
SMART
 SM00408; IGc2
 SM00130; KR
 SM00219; TyrKc 
PROSITE
 PS50038; FZ
 PS50835; IG_LIKE
 PS00021; KRINGLE_1
 PS50070; KRINGLE_2
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.