CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007461
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 B-cell lymphoma 6 protein 
Protein Synonyms/Alias
 BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51 
Gene Name
 BCL6 
Gene Synonyms/Alias
 BCL5; LAZ3; ZBTB27; ZNF51 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
282YSVAEGLKPAAPSARubiquitination[1]
379ACNWKKYKFIVLNSLacetylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Acetylation inactivates the transcriptional repressor BCL6.
 Bereshchenko OR, Gu W, Dalla-Favera R.
 Nat Genet. 2002 Dec;32(4):606-13. [PMID: 12402037] 
Functional Description
 Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis. 
Sequence Annotation
 DOMAIN 32 99 BTB.
 ZN_FING 518 541 C2H2-type 1.
 ZN_FING 546 568 C2H2-type 2.
 ZN_FING 574 596 C2H2-type 3.
 ZN_FING 602 624 C2H2-type 4.
 ZN_FING 630 652 C2H2-type 5.
 ZN_FING 658 681 C2H2-type 6.
 MOD_RES 333 333 Phosphoserine; by MAPK1.
 MOD_RES 343 343 Phosphoserine; by MAPK1.  
Keyword
 3D-structure; Activator; Alternative splicing; Chromosomal rearrangement; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 60
FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 120
CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF 180
APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG 240
EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS 300
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS KNACILQASG 360
SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL GRLSPRAYTA PPACQPPMEP 420
ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS 480
QSPQHAEMCL HTAGPTFPEE MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT 540
HSDKPYKCDR CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK 600
PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR IHTGEKPYHC 660
EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP ELPKAC 706 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0031490; F:chromatin DNA binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
 GO:0030183; P:B cell differentiation; IEA:Compara.
 GO:0000902; P:cell morphogenesis; IEA:Compara.
 GO:0048821; P:erythrocyte development; IEA:Compara.
 GO:0002467; P:germinal center formation; IEA:Compara.
 GO:0002903; P:negative regulation of B cell apoptotic process; NAS:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Compara.
 GO:0048294; P:negative regulation of isotype switching to IgE isotypes; IEA:Compara.
 GO:0032764; P:negative regulation of mast cell cytokine production; IEA:Compara.
 GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Compara.
 GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0002829; P:negative regulation of type 2 immune response; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
 GO:0030890; P:positive regulation of B cell proliferation; IEA:Compara.
 GO:0051272; P:positive regulation of cellular component movement; IEA:Compara.
 GO:0000060; P:protein import into nucleus, translocation; IGI:UniProtKB.
 GO:0002634; P:regulation of germinal center formation; NAS:UniProtKB.
 GO:0050727; P:regulation of inflammatory response; IEA:Compara.
 GO:0043380; P:regulation of memory T cell differentiation; IEA:Compara.
 GO:0032319; P:regulation of Rho GTPase activity; IEA:Compara.
 GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.
 GO:0007266; P:Rho protein signal transduction; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0042092; P:type 2 immune response; IEA:Compara. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS