CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034325
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear receptor corepressor 2 
Protein Synonyms/Alias
  
Gene Name
 Ncor2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
372RASTSPQKPLDLKQLacetylation[1]
587LAPFSGVKQEQLSPRacetylation[1]
953VVVPELGKPRQSPLTacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1025 AA 
Protein Sequence
MFPENLAEGE TQMRGCLLEH GRNWSAIARM VGSKTVSQCK NFYFNYKKRQ NLDEILQQHK 60
LKMPGPGLRH RASPAVTATV LSQEKERNAR RKKKKTPAAA SEETAFPPAA EDEEMEASGA 120
SANEEELAEE AEASQASGNE VPRVGECSGP AAVNNSSDTE SVPSPRSEAT KDTGPKPTGT 180
EALPAATQPP VPPPEEPAVA PAEPSPVPDA SGPPSPEPSP SPAAPPATVD KDEQEAPAAP 240
APQTEDAKEQ KSEAEEIDVG KPEEPEASEE PPESVKSDHK EETEEEPEDK AKGTEAIETV 300
SEAPLKVEEA GSKAAVTKGS SSGATQDSDS SATCSADEVD EPEGGDKGRL LSPRPSLLTP 360
AGDPRASTSP QKPLDLKQLK QRAAAIPPIV TKVHEPPRED TVPPKPVPPV PPPTQHLQPE 420
GDVSQQSGGS PRGKSRSPVP PAEKEAEKPA FFPAFPTEGP KLPTEPPRWS SGLPFPIPPR 480
EVIKTSPHAA DPSAFSYTPP GHPLPLGLHD SARPVLPRPP ISNPPPLISS AKHPGVLERQ 540
LGAISQGMSV QLRVPHSEHA KAPMGPLTMG LPLAVDPKKL APFSGVKQEQ LSPRGQAGPP 600
ESLGVPTAQE TSVLRGTALG SATSGSITKG LPSTRAADGP SYRGSITHGT PADVLYKGTI 660
SRIVGEDSPS RLDRAREDTL PKGHVIYEGK KGHVLSYEGG MSVSQCSKED GRSSSGPPHE 720
TAAPKRTYDM MEGRVGRTVT SASIEGLMGR AIPEQHSPHL KEQHHIRGSI TQGIPRSYVE 780
AQEDYLRREA KLLKREGTPP PPPPPRDLTE TYKPRPLDPL GPLKLKPTHE GVVATVKEAG 840
RSIHEIPREE LRRTPELPLA PRPLKEGSIT QGTPLKYDSG APSTGTKKHD VRSIIGSPGR 900
PFPALHPLDI MADARALERA CYEESLKSRS GTSSGAGGSI TRGAPVVVPE LGKPRQSPLT 960
YEDHGAPFTS HLPRGSPVTT REPTPRLQEG SLLSSKASQD RKLTSTPREI AKSPHSTVPE 1020
HHPHP 1025 
Gene Ontology
 GO:0000118; C:histone deacetylase complex; IDA:MGI.
 GO:0016604; C:nuclear body; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IMP:MGI.
 GO:0021846; P:cell proliferation in forebrain; IMP:MGI.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0045599; P:negative regulation of fat cell differentiation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0021537; P:telencephalon development; IMP:MGI.
 GO:0050872; P:white fat cell differentiation; IMP:MGI. 
Interpro
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom. 
Pfam
 PF00249; Myb_DNA-binding 
SMART
 SM00717; SANT 
PROSITE
 PS51293; SANT 
PRINTS