UniProt Accession

 ECHD1_HUMAN; Q9NTX5; A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NZ30 

Genbank Protein ID

 AL834469; AK303812; AF220192; AL109939; AL109939; AL109939; AL109939; AL109939; CH471051; BC003549 

Genbank Nucleotide ID

 CAD39128.1; BAH14056.1; AAF67657.1; CAB76256.1; CAI20295.1; CAI20297.1; CAI20302.1; CAI20298.1; EAW48107.1; AAH03549.1 

Protein Name

 Ethylmalonyl-CoA decarboxylase 

Protein Synonyms/Alias

 Enoyl-CoA hydratase domain-containing protein 1; Methylmalonyl-CoA decarboxylase; MMCD 

Gene Name

 ECHDC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	GSDLNAVKSLGTPET	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activityx at lower level. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Lyase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 307 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0016831; F:carboxy-lyase activity; ISS:UniProtKB.
 GO:0004492; F:methylmalonyl-CoA decarboxylase activity; IEA:EC. 

Interpro

 IPR001753; Crotonase_core_superfam.
 IPR018376; Enoyl-CoA_hyd/isom_CS. 

Pfam

 PF00378; ECH 

SMART

  

PROSITE

 PS00166; ENOYL_COA_HYDRATASE 

PRINTS