UniProt Accession

 STABP_MOUSE; Q9CQ26; Q3UTI9 

Genbank Protein ID

 AB010123; AK017600; AK019907; AK136961; AK139391; BC003497; BC006939; BC025111 

Genbank Nucleotide ID

 BAB78604.1; BAB30832.1; BAB31909.1; BAE23188.1; BAE23991.1; AAH03497.1; AAH06939.1; AAH25111.1 

Protein Name

 STAM-binding protein 

Protein Synonyms/Alias

 Associated molecule with the SH3 domain of STAM 

Gene Name

 Stambp 

Gene Synonyms/Alias

 Amsh 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
107	FPKAEELKTELLRRY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of AMSH is required for efficient EGFR degradation but not for its internalization. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (By similarity). 

Sequence Annotation

 DOMAIN 252 361 MPN.
 REGION 1 127 Interaction with CHMP3 (By similarity).
 REGION 227 231 Interaction with STAM1 (By similarity).
 MOTIF 335 348 JAMM motif.
 METAL 335 335 Zinc 1; catalytic (By similarity).
 METAL 337 337 Zinc 1; catalytic (By similarity).
 METAL 348 348 Zinc 1; catalytic (By similarity).
 METAL 350 350 Zinc 2 (By similarity).
 METAL 390 390 Zinc 2 (By similarity).
 METAL 396 396 Zinc 2 (By similarity).
 METAL 398 398 Zinc 2 (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 48 48 Phosphoserine (By similarity).
 MOD_RES 243 243 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Endosome; Hydrolase; Membrane; Metal-binding; Metalloprotease; Nucleus; Phosphoprotein; Protease; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 424 AA 

Protein Sequence

Gene Ontology

 GO:0032154; C:cleavage furrow; IDA:MGI.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0004843; F:ubiquitin-specific protease activity; IEA:Compara.
 GO:0000281; P:mitotic cytokinesis; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0016579; P:protein deubiquitination; IMP:MGI.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; TAS:MGI. 

Interpro

 IPR000555; JAB1_Mov34_MPN_PAD1. 

Pfam

 PF01398; JAB 

SMART

 SM00232; JAB_MPN 

PROSITE

  

PRINTS