CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019159
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methyl-CpG-binding domain protein 6 
Protein Synonyms/Alias
 Methyl-CpG-binding protein MBD6 
Gene Name
 MBD6 
Gene Synonyms/Alias
 KIAA1887 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
956SRRGRRRKYNPTRNSacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro). 
Sequence Annotation
 DOMAIN 11 81 MBD.  
Keyword
 Chromosome; Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1003 AA 
Protein Sequence
MNGGNESSGA DRAGGPVATS VPIGWQRCVR EGAVLYISPS GTELSSLEQT RSYLLSDGTC 60
KCGLECPLNV PKVFNFDPLA PVTPGGAGVG PASEEDMTKL CNHRRKAVAM ATLYRSMETT 120
CSHSSPGEGA SPQMFHTVSP GPPSARPPCR VPPTTPLNGG PGSLPPEPPS VSQAFPTLAG 180
PGGLFPPRLA DPVPSGGSSS PRFLPRGNAP SPAPPPPPAI SLNAPSYNWG AALRSSLVPS 240
DLGSPPAPHA SSSPPSDPPL FHCSDALTPP PLPPSNNLPA HPGPASQPPV SSATMHLPLV 300
LGPLGGAPTV EGPGAPPFLA SSLLSAAAKA QHPPLPPPST LQGRRPRAQA PSASHSSSLR 360
PSQRRPRRPP TVFRLLEGRG PQTPRRSRPR APAPVPQPFS LPEPSQPILP SVLSLLGLPT 420
PGPSHSDGSF NLLGSDAHLP PPPTLSSGSP PQPRHPIQPS LPGTTSGSLS SVPGAPAPPA 480
ASKAPVVPSP VLQSPSEGLG MGAGPACPLP PLAGGEAFPF PSPEQGLALS GAGFPGMLGA 540
LPLPLSLGQP PPSPLLNHSL FGVLTGGGGQ PPPEPLLPPP GGPGPPLAPG EPEGPSLLVA 600
SLLPPPPSDL LPPPSAPPSN LLASFLPLLA LGPTAGDGEG SAEGAGGPSG EPFSGLGDLS 660
PLLFPPLSAP PTLIALNSAL LAATLDPPSG TPPQPCVLSA PQPGPPTSSV TTATTDPGAS 720
SLGKAPSNSG RPPQLLSPLL GASLLGDLSS LTSSPGALPS LLQPPGPLLS GQLGLQLLPG 780
GGAPPPLSEA SSPLACLLQS LQIPPEQPEA PCLPPESPAS ALEPEPARPP LSALAPPHGS 840
PDPPVPELLT GRGSGKRGRR GGGGLRGING EARPARGRKP GSRREPGRLA LKWGTRGGFN 900
GQMERSPRRT HHWQHNGELA EGGAEPKDPP PPGPHSEDLK VPPGVVRKSR RGRRRKYNPT 960
RNSNSSRQDI TLEPSPTARA AVPLPPRARP GRPAKNKRRK LAP 1003 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003682; F:chromatin binding; IDA:UniProtKB. 
Interpro
 IPR001739; Methyl_CpG_DNA-bd. 
Pfam
  
SMART
  
PROSITE
 PS50982; MBD 
PRINTS