UniProt Accession

 NMDE2_HUMAN; Q13224; Q12919; Q13220; Q13225; Q14CU4; Q9UM56 

Genbank Protein ID

 U90278; U88963; U11287; BC113618; BC113620; U28758; U28861; U28862 

Genbank Nucleotide ID

 AAB49993.1; AAD00659.1; AAB60368.1; AAI13619.1; AAI13621.1; AAA74930.1; AAA69919.1; AAA69920.1 

Protein Name

 Glutamate receptor ionotropic, NMDA 2B 

Protein Synonyms/Alias

 GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3 

Gene Name

 GRIN2B 

Gene Synonyms/Alias

 NMDAR2B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
1280	TSNASTTKYPQSPTN	acetylation	[1]
1289	PQSPTNSKAQKKNRN	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). 

Sequence Annotation

 REGION 1292 1304 Interaction with DAPK1 (By similarity).
 MOTIF 1482 1484 PDZ-binding (By similarity).
 METAL 127 127 Zinc (By similarity).
 METAL 284 284 Zinc (By similarity).
 MOD_RES 917 917 Phosphoserine (By similarity).
 MOD_RES 930 930 Phosphoserine (By similarity).
 MOD_RES 932 932 Phosphotyrosine (By similarity).
 MOD_RES 949 949 Phosphotyrosine (By similarity).
 MOD_RES 962 962 Phosphotyrosine (By similarity).
 MOD_RES 1039 1039 Phosphotyrosine (By similarity).
 MOD_RES 1049 1049 Phosphotyrosine (By similarity).
 MOD_RES 1061 1061 Phosphoserine (By similarity).
 MOD_RES 1065 1065 Phosphothreonine (By similarity).
 MOD_RES 1070 1070 Phosphotyrosine (By similarity).
 MOD_RES 1109 1109 Phosphotyrosine (By similarity).
 MOD_RES 1155 1155 Phosphotyrosine (By similarity).
 MOD_RES 1166 1166 Phosphoserine (By similarity).
 MOD_RES 1252 1252 Phosphotyrosine (By similarity).
 MOD_RES 1303 1303 Phosphoserine; by DAPK1 (By similarity).
 MOD_RES 1474 1474 Phosphotyrosine (By similarity).
 CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
 CARBOHYD 341 341 N-linked (GlcNAc...) (Potential).
 CARBOHYD 348 348 N-linked (GlcNAc...) (Potential).
 CARBOHYD 444 444 N-linked (GlcNAc...) (Potential).
 CARBOHYD 491 491 N-linked (GlcNAc...) (Potential).
 CARBOHYD 542 542 N-linked (GlcNAc...) (Potential).
 CARBOHYD 688 688 N-linked (GlcNAc...) (Potential).
 DISULFID 86 321 By similarity.  

Keyword

 3D-structure; Calcium; Cell junction; Cell membrane; Chromosomal rearrangement; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Magnesium; Membrane; Mental retardation; Metal-binding; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1484 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; ISS:BHF-UCL.
 GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IDA:UniProtKB.
 GO:0043005; C:neuron projection; ISS:BHF-UCL.
 GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0005262; F:calcium channel activity; IEA:Compara.
 GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro.
 GO:0016594; F:glycine binding; IDA:UniProtKB.
 GO:0004972; F:N-methyl-D-aspartate selective glutamate receptor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0001662; P:behavioral fear response; IEA:Compara.
 GO:0048266; P:behavioral response to pain; IEA:Compara.
 GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0007612; P:learning; IEA:Compara.
 GO:0007611; P:learning or memory; TAS:ProtInc.
 GO:0007613; P:memory; IEA:Compara.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0048167; P:regulation of synaptic plasticity; IEA:Compara.
 GO:0045471; P:response to ethanol; IDA:UniProtKB.
 GO:0007423; P:sensory organ development; IEA:Compara.
 GO:0001964; P:startle response; IEA:Compara.
 GO:0001967; P:suckling behavior; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR001828; ANF_lig-bd_rcpt.
 IPR019594; Glu_rcpt_Glu/Gly-bd.
 IPR001320; Iontro_glu_rcpt.
 IPR001508; NMDA_rcpt.
 IPR018884; NMDAR2_C.
 IPR001638; SBP_bac_3. 

Pfam

 PF01094; ANF_receptor
 PF00060; Lig_chan
 PF10565; NMDAR2_C
 PF00497; SBP_bac_3 

SMART

 SM00918; Lig_chan-Glu_bd
 SM00079; PBPe 

PROSITE

  

PRINTS

 PR00177; NMDARECEPTOR.