| Tag | Content |
|---|
| CPLM ID | CPLM-006067 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3'(2'),5'-bisphosphate nucleotidase |
Protein Synonyms/Alias | 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; DPNPase; Halotolerance protein HAL2; Methionine-requiring protein 22 |
Gene Name | MET22 |
Gene Synonyms/Alias | HAL2; YOL064C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 285 | VYLRLPIKLSYQEKI | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance. Confers resistance to lithium. |
Sequence Annotation | REGION 144 147 Substrate binding (By similarity).
METAL 72 72 Magnesium 1.
METAL 142 142 Magnesium 1.
METAL 142 142 Magnesium 2.
METAL 144 144 Magnesium 1; via carbonyl oxygen.
METAL 145 145 Magnesium 2.
METAL 294 294 Magnesium 2.
BINDING 72 72 Substrate (By similarity).
BINDING 294 294 Substrate (By similarity). |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Lithium; Magnesium; Metal-binding; Nucleus; Reference proteome; Stress response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 357 AA |
Protein Sequence | MALERELLVA TQAVRKASLL TKRIQSEVIS HKDSTTITKN DNSPVTTGDY AAQTIIINAI 60
KSNFPDDKVV GEESSSGLSD AFVSGILNEI KANDEVYNKN YKKDDFLFTN DQFPLKSLED 120
VRQIIDFGNY EGGRKGRFWC LDPIDGTKGF LRGEQFAVCL ALIVDGVVQL GCIGCPNLVL 180
SSYGAQDLKG HESFGYIFRA VRGLGAFYSP SSDAESWTKI HVRHLKDTKD MITLEGVEKG 240
HSSHDEQTAI KNKLNISKSL HLDSQAKYCL LALGLADVYL RLPIKLSYQE KIWDHAAGNV 300
IVHEAGGIHT DAMEDVPLDF GNGRTLATKG VIASSGPREL HDLVVSTSCD VIQSRNA 357 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0008441; F:3'(2'),5'-bisphosphate nucleotidase activity; IDA:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0042538; P:hyperosmotic salinity response; IMP:SGD. GO:0009086; P:methionine biosynthetic process; IMP:SGD. GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. GO:0000103; P:sulfate assimilation; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |