UniProt Accession

 CDCA7_HUMAN; Q9BWT1; Q53EW5; Q580W9; Q658K4; Q658N4; Q8NBY9; Q96BV8; Q96SP5 

Genbank Protein ID

 AY029179; AK027628; AK027642; AK075134; AK223524; AL833728; AL834186; AC092573; BC015124; BC027966; BG354580 

Genbank Nucleotide ID

 AAK31591.1; BAB55245.1; BAB55258.1; BAC11425.1; BAD97244.1; CAH56253.1; CAH56357.1; AAX82003.1; AAH15124.1; AAH27966.1 

Protein Name

 Cell division cycle-associated protein 7 

Protein Synonyms/Alias

 Protein JPO1 

Gene Name

 CDCA7 

Gene Synonyms/Alias

 JPO1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
9	DARRVPQKDLRVKKN	ubiquitination	[1]
154	GPLRVAMKFPARSTR	ubiquitination	[1]
202	EKRALNIKQNKAMLA	ubiquitination	[1, 2]
205	ALNIKQNKAMLAKLM	ubiquitination	[1]
210	QNKAMLAKLMSELES	ubiquitination	[1]
283	EEEEEEDKYMLVRKR	ubiquitination	[1]
289	DKYMLVRKRKTVDGY	ubiquitination	[2]
291	YMLVRKRKTVDGYMN	ubiquitination	[1, 2]
428	GVLVYLAKYHGFGNV	ubiquitination	[1]
440	GNVHAYLKSLKQEFE	ubiquitination	[1]
443	HAYLKSLKQEFEMQA	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Participates in MYC-mediated cell transformation; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. 

Sequence Annotation

 REGION 247 371 Mediates transcriptional activity.
 MOD_RES 190 190 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0042127; P:regulation of cell proliferation; IDA:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR018866; Znf-4CXXC_R1. 

Pfam

 PF10497; zf-4CXXC_R1 

SMART

  

PROSITE

  

PRINTS