UniProt Accession

 F6VNW5_MOUSE; F6VNW5 

Genbank Protein ID

 AC134918 

Genbank Nucleotide ID

  

Protein Name

 Glutamate--cysteine ligase regulatory subunit 

Protein Synonyms/Alias

  

Gene Name

 Gclm 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
34	PDEREEMKVSAKLFI	acetylation	[1]
34	PDEREEMKVSAKLFI	ubiquitination	[2]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0017109; C:glutamate-cysteine ligase complex; IDA:MGI.
 GO:0035226; F:glutamate-cysteine ligase catalytic subunit binding; IDA:MGI.
 GO:0006534; P:cysteine metabolic process; IMP:MGI.
 GO:0006750; P:glutathione biosynthetic process; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IGI:MGI.
 GO:0035229; P:positive regulation of glutamate-cysteine ligase activity; IDA:MGI.
 GO:0051900; P:regulation of mitochondrial depolarization; IGI:MGI.
 GO:0006979; P:response to oxidative stress; IMP:MGI. 

Interpro

 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

  

PRINTS