UniProt Accession

 COTL1_MOUSE; Q9CQI6 

Genbank Protein ID

 AK010052; AK007994; AK008085; BC011068; BC010249 

Genbank Nucleotide ID

 BAB26668.1; BAB25396.1; BAB25450.1; AAH11068.1; AAH10249.1 

Protein Name

 Coactosin-like protein 

Protein Synonyms/Alias

  

Gene Name

 Cotl1 

Gene Synonyms/Alias

 Clp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MATKIDKEACRAAY	acetylation	[1]
75	DAMSKRSKFALITWI	acetylation	[1]
102	GTDKTLVKEVVQNFA	acetylation	[1]
102	GTDKTLVKEVVQNFA	ubiquitination	[2]
110	EVVQNFAKEFVISDR	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity). 

Sequence Annotation

 DOMAIN 2 130 ADF-H.
 REGION 66 75 Flexible and important for F-actin
 MOD_RES 102 102 N6-acetyllysine (By similarity).
 MOD_RES 141 141 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Actin-binding; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0050832; P:defense response to fungus; IDA:UniProtKB. 

Interpro

 IPR002108; Actin-bd_cofilin/tropomyosin. 

Pfam

 PF00241; Cofilin_ADF 

SMART

 SM00102; ADF 

PROSITE

 PS51263; ADF_H 

PRINTS