CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006642
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 76 
Protein Synonyms/Alias
 Zinc finger protein 523 
Gene Name
 ZNF76 
Gene Synonyms/Alias
 D6S229E; ZNF523 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
183YTTAHHLKVHERAHTubiquitination[1]
204CDFPSCGKAFATGYGubiquitination[1]
213FATGYGLKSHVRTHTubiquitination[1]
411IAYLSEVKEERDDIPsumoylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation.
 Zheng G, Yang YC.
 J Biol Chem. 2004 Oct 8;279(41):42410-21. [PMID: 15280358] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 REPEAT 34 45 1.
 REPEAT 62 73 2.
 REPEAT 88 99 3.
 ZN_FING 165 189 C2H2-type 1.
 ZN_FING 195 219 C2H2-type 2.
 ZN_FING 225 249 C2H2-type 3.
 ZN_FING 255 279 C2H2-type 4.
 ZN_FING 285 309 C2H2-type 5.
 ZN_FING 315 339 C2H2-type 6.
 ZN_FING 345 368 C2H2-type 7.
 REGION 34 99 3 X 12 AA approximate repeats.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 570 AA 
Protein Sequence
MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ KEALSFEDGQ 60
PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH PVAVPSESTI LAVQTEVGLE 120
DLAAEDDEGF SADAVVALEQ YASKVLHDSQ IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH 180
HLKVHERAHT GDRPYRCDFP SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG 240
DLQKHVRTHT GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT 300
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC GKTYRQTSTL 360
AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK RPRIAYLSEV KEERDDIPAQ 420
VAMVTEEDGA PQVALITQDG AQQVSLSPED LQALGSAISM VTQHGSTTLT IPSPDADLAT 480
SGTHTVTMVS ADGTQTQPVT IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ 540
QTLEEAINVA TAAMQQGAVT LETTVSESGC 570 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006359; P:regulation of transcription from RNA polymerase III promoter; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS