CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044436
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase PLK4 
Protein Synonyms/Alias
  
Gene Name
 PLK4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MATCIGEKIEDFKVGubiquitination[1]
13GEKIEDFKVGNLLGKubiquitination[1]
151LTRNMNIKIADFGLAubiquitination[1]
162FGLATQLKMPHEKHYubiquitination[1]
167QLKMPHEKHYTLCGTubiquitination[1]
321IGQPLPNKMTVFPKNubiquitination[1, 2]
327NKMTVFPKNKSSTDFubiquitination[1]
329MTVFPKNKSSTDFSSubiquitination[1]
392SNSQSQAKTYTMERCubiquitination[1]
436IFNFFKEKTSSSSGSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 892 AA 
Protein Sequence
MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60
VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRVKPFSE NEARHFMHQI 120
ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180
EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PSFLSIEAKD 240
LIHQLLRRNP ADRLSLSSVL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST 300
SISGSLFDKR RLLIGQPLPN KMTVFPKNKS STDFSSSGDG NSFYTQWGNQ ETSNSGRGRV 360
IQDAEERPHS RYLRRAYSSD RSGTSNSQSQ AKTYTMERCH SAEMLSVSKR SGGGENEERY 420
SPTDNNANIF NFFKEKTSSS SGSFERPDNN QALSNHLCPG KTPFPFADPT PQTETVQQWF 480
GNLQINDPLS EQSKTRGMEP PWGYQNRTLR SITSPLVAHR LKPIRQKTKK AVVSILDSEE 540
VCVELVKEYA SQEYVKEVLQ ISSDGNTITI YYPNGGRGFP LADRPPSPTD NISRYSFDNL 600
PEKYWRKYQY ASRFVQLVRS KSPKITYFTR YAKCILMENS PGADFEVWFY DGVKIHKTED 660
FIQVIEKTGK SYTLKSESEV NSLKEEIKMY MDHANEGHRI CLALESIISE EERKTRSAPF 720
FPIIIGRKPG STSSPKALSP PPSVDSNYPT RERASFNRMV MHSAASPTQA PILNPSMVTN 780
EGLGLTTTAS GTDISSNSLK DCLPKSAQLL KSVFVKNVGW ATQLTSGAVW VQFNDGSQLV 840
VQAGVSSISY TSPNGQTTRY GENEKLPDYI KQKLQCLSSI LLMFSNPTPN FH 892 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000959; POLO_box_duplicated_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008266; Tyr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00659; POLO_box 
SMART
 SM00220; S_TKc 
PROSITE
 PS50078; POLO_BOX
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS