UniProt Accession

 DMA_MOUSE; P28078 

Genbank Protein ID

 X62742 

Genbank Nucleotide ID

 CAA44604.1 

Protein Name

 Class II histocompatibility antigen, M alpha chain 

Protein Synonyms/Alias

  

Gene Name

 H2-DMa 

Gene Synonyms/Alias

 H2-Ma; Ma 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MEHEQKSGAVLLR	acetylation	[1]
6	**MEHEQKSGAVLLR	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides. 

Sequence Annotation

 DOMAIN 114 215 Ig-like C1-type.
 REGION 27 124 Alpha-1.
 REGION 125 217 Alpha-2.
 REGION 218 231 Connecting peptide (Potential).
 CARBOHYD 41 41 N-linked (GlcNAc...).
 DISULFID 50 105
 DISULFID 147 202  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Endosome; Glycoprotein; Immunity; Lysosome; Membrane; MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0010008; C:endosome membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IDA:MGI.
 GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
 GO:0005771; C:multivesicular body; IDA:MGI.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IDA:MGI.
 GO:0051085; P:chaperone mediated protein folding requiring cofactor; IDA:MGI.
 GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.
 GO:0048839; P:inner ear development; IDA:MGI.
 GO:0002636; P:positive regulation of germinal center formation; IMP:BHF-UCL.
 GO:0002922; P:positive regulation of humoral immune response; IMP:BHF-UCL.
 GO:0045582; P:positive regulation of T cell differentiation; IMP:MGI.
 GO:0045059; P:positive thymic T cell selection; IMP:MGI.
 GO:0006461; P:protein complex assembly; IDA:MGI.
 GO:0015031; P:protein transport; IDA:MGI. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR014745; MHC_II_a/b_N.
 IPR001003; MHC_II_a_N. 

Pfam

 PF07654; C1-set
 PF00993; MHC_II_alpha 

SMART

 SM00407; IGc1
 SM00920; MHC_II_alpha 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS