| Tag | Content |
|---|
| CPLM ID | CPLM-032546 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Bifunctional dihydrofolate reductase-thymidylate synthase |
Protein Synonyms/Alias | |
Gene Name | TGGT1_100740, TGME49_049180, TGVEG_002710 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Toxoplasma gondii |
NCBI Taxa ID | 5811 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 352 | TGVGVISKFGCTMRY | acetylation | [1] | | 405 | KGVKIWDKNVTREFL | acetylation | [1] |
|
Reference | [1] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii. Xue B, Jeffers V, Sullivan WJ, Uversky VN. Mol Biosyst. 2013 Apr 5;9(4):645-57. [ PMID: 23403842] |
Functional Description | Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity). |
Sequence Annotation | ACT_SITE 489 489 By similarity. |
Keyword | Complete proteome; Methyltransferase; Nucleotide biosynthesis; One-carbon metabolism; Oxidoreductase; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 610 AA |
Protein Sequence | MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN GWLPRKFAKT 60
GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI VVSSSLKEED IAAEKPQAEG 120
QQRVRVCASL PAALSLLEEE YKDSVDQIFV VGGAGLYEAA LSLGVASHLY ITRVAREFPC 180
DVFFPAFPGD DILSNKSTAA QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG 240
VPYDFVVLEK RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE 300
DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI SKFGCTMRYS 360
LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV KIWDKNVTRE FLDSRNLPHR 420
EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA 480
LDEMALPPCH LLCQFYVNDQ KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP 540
KEFIHFMGNT HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP 600
HGRIQMEMAV 610 |
Gene Ontology | GO:0004146; F:dihydrofolate reductase activity; IEA:InterPro. GO:0004799; F:thymidylate synthase activity; IEA:InterPro. GO:0006231; P:dTMP biosynthetic process; IEA:InterPro. GO:0006545; P:glycine biosynthetic process; IEA:InterPro. GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |