UniProt Accession

 FSCN1_MOUSE; Q61553; O09099; O09156; Q05DK3; Q7TN32; Q80V75 

Genbank Protein ID

 L33726; U90355; AK167670; BC010338; BC037137; BC052408 

Genbank Nucleotide ID

 AAB41126.1; AAB58784.1; BAE39719.1; AAH10338.1; AAH37137.2; AAH52408.1 

Protein Name

 Fascin 

Protein Synonyms/Alias

 Singed-like protein 

Gene Name

 Fscn1 

Gene Synonyms/Alias

 Fan1; Snl 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
41	NASASSLKKKQIWTL	acetylation	[1]
41	NASASSLKKKQIWTL	succinylation	[1]
43	SASSLKKKQIWTLEQ	acetylation	[2]
74	GRYLAADKDGNVTCE	acetylation	[1, 2]
74	GRYLAADKDGNVTCE	ubiquitination	[3]
241	SGPSGTLKAGKATKV	ubiquitination	[3]
399	HGFIGCRKVTGTLDA	ubiquitination	[3]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 38 38 Phosphoserine (By similarity).
 MOD_RES 39 39 Phosphoserine; by PKC (By similarity).  

Keyword

 Acetylation; Actin-binding; Cell junction; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 493 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030175; C:filopodium; IDA:MGI.
 GO:0071437; C:invadopodium; ISS:UniProtKB.
 GO:0001725; C:stress fiber; ISS:UniProtKB.
 GO:0051015; F:actin filament binding; IMP:MGI.
 GO:0008144; F:drug binding; IDA:UniProtKB.
 GO:0051017; P:actin filament bundle assembly; IDA:MGI.
 GO:0016477; P:cell migration; IMP:UniProtKB. 

Interpro

 IPR008999; Actin_cross-linking.
 IPR010431; Fascin.
 IPR022768; Fascin-domain.
 IPR024703; Fascin_metazoans. 

Pfam

 PF06268; Fascin 

SMART

  

PROSITE

  

PRINTS