CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021326
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 245 
Protein Synonyms/Alias
 Protein CG-2 
Gene Name
 TMEM245 
Gene Synonyms/Alias
 C9orf5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
436GLGKFLLKVDSKLWHubiquitination[1]
541GREWITHKLHKILGDubiquitination[2]
549LHKILGDKVNNTAVIubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 16 16 Phosphoserine (By similarity).
 MOD_RES 36 36 Phosphothreonine.
 MOD_RES 332 332 Phosphoserine.
 MOD_RES 334 334 Phosphothreonine.
 CARBOHYD 210 210 N-linked (GlcNAc...) (Potential).
 CARBOHYD 500 500 N-linked (GlcNAc...) (Potential).
 CARBOHYD 551 551 N-linked (GlcNAc...).
 CARBOHYD 575 575 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 911 AA 
Protein Sequence
MADGGGPKDA PSLRSSPGPA PRVPRAVGPS GGGGETPRTA ALALRFDKPI KQAFYNTGAV 60
LFVCLCCGAA VLVYFILEAF LRPLLWAVLC GTFLHPFKSS LTRLGRHWLQ RLHRAHTPIV 120
LAALLLPLCF VDYGVEALGE QALRRRRLLL LLGAGGPLLY GLYCLGSYLG VQVLLVHAAT 180
LICRGLDYFS SLWIWTLVVG YVLTVSFKWN ASTERYLRAV SIPVWIILLF HLASLAGSWR 240
IPVFLVIVFL MSVGTLYEKQ NGKESSGAEL PGQVISMAAS TLANLAISIT GYESSSEDQP 300
STQPAEAVDR GESAPTLSTS PSPSSPSPTS PSPTLGRRRP EIGTFLRKKK TSDIYFVSLV 360
WAIVVMQIWL NLWIVQLLPV PIAVWILKKL VIHFGVVDFL EKRYHVWWGI IESFLKERQG 420
ALAPWPIVGL GKFLLKVDSK LWHWLNKKMI IWLEKMLDKI ISIFIIFLLV IGTLLLALLL 480
TAKVHQESVH MIEVTSNLIN ETLANHPEWA NWLPEAQVVQ RALNSAANNV YQYGREWITH 540
KLHKILGDKV NNTAVIEKQV LELWDRLYHS WFVKNVTHSG RHKGQKLHVS RQNSWLGDIL 600
DWQDIVSFVH ENIETFLSIL ESLWIVMSRN VSLLFTTVTT LLTILFYSGT ALLNFVLSLI 660
IFLTTLFYLL SSSDEYYKPV KWVISLTPLS QPGPSSNIIG QSVEEAIRGV FDASLKMAGF 720
YGLYTWLTHT MFGINIVFIP SALAAILGAV PFLGTYWAAV PAVLDLWLTQ GLGCKAILLL 780
IFHLLPTYFV DTAIYSDISG GGHPYLTGLA VAGGAYYLGL EGAIIGPILL CILVVASNIY 840
SAMLVSPTNS VPTPNQTPWP AQPQRTFRDI SERSEIFSKV DVVSSAVIFL RKFKFDSEFS 900
SAVAFCPSSC A 911 
Gene Ontology
 GO:0016021; C:integral to membrane; NAS:UniProtKB. 
Interpro
 IPR002549; UPF0118. 
Pfam
 PF01594; UPF0118 
SMART
  
PROSITE
  
PRINTS