CPLM-002615

Genbank Nucleotide ID

4F2 cell-surface antigen heavy chain

Protein Synonyms/Alias

4F2hc; 4F2 heavy chain antigen; Lymphocyte activation antigen 4F2 large subunit; CD98

Homo sapiens (Human)

Position	Peptide	Type	References
49	QDTEVDMKEVELNEL	ubiquitination	[1]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.

MOD_RES 1 1 N-acetylmethionine.
MOD_RES 103 103 Phosphoserine.
MOD_RES 134 134 Phosphoserine.
MOD_RES 165 165 Phosphoserine.
MOD_RES 406 406 Phosphoserine (Probable).
MOD_RES 408 408 Phosphoserine (Probable).
MOD_RES 410 410 Phosphoserine (Probable).
MOD_RES 527 527 Phosphoserine (Probable).
MOD_RES 531 531 Phosphoserine (Probable).
CARBOHYD 365 365 N-linked (GlcNAc...).
CARBOHYD 381 381 N-linked (GlcNAc...).
CARBOHYD 424 424 N-linked (GlcNAc...).
CARBOHYD 506 506 N-linked (GlcNAc...).
DISULFID 210 210 Interchain (with light chain).
CROSSLNK 147 147 Glycyl lysine isopeptide (Lys-Gly)

3D-structure; Acetylation; Alternative splicing; Amino-acid transport; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Isopeptide bond; Membrane; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Transport; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0016021; C:integral to membrane; NAS:UniProtKB.
GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005432; F:calcium:sodium antiporter activity; TAS:UniProtKB.
GO:0003824; F:catalytic activity; IEA:InterPro.
GO:0043169; F:cation binding; IEA:InterPro.
GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
GO:0007596; P:blood coagulation; TAS:Reactome.
GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
GO:0016049; P:cell growth; NAS:UniProtKB.
GO:0060356; P:leucine import; ISS:UniProtKB.
GO:0050900; P:leukocyte migration; TAS:Reactome.
GO:0015827; P:tryptophan transport; ISS:UniProtKB.

IPR015902; Glyco_hydro_13.
IPR013780; Glyco_hydro_13_b.
IPR006047; Glyco_hydro_13_cat_dom.
IPR013781; Glyco_hydro_catalytic_dom.
IPR017853; Glycoside_hydrolase_SF.

PF00128; Alpha-amylase