UniProt Accession

 PRDX1_RAT; Q63716 

Genbank Protein ID

 D30035; BC058450; BC088118 

Genbank Nucleotide ID

 BAA06275.1; AAH58450.1; AAH88118.1 

Protein Name

 Peroxiredoxin-1 

Protein Synonyms/Alias

 HBP23; Heme-binding 23 kDa protein; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2 

Gene Name

 Prdx1 

Gene Synonyms/Alias

 Tdpx2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
16	GHPAPSFKATAVMPD	acetylation	[1]
27	VMPDGQFKDISLSDY	acetylation	[1]
35	DISLSDYKGKYVVFF	acetylation	[1]
35	DISLSDYKGKYVVFF	ubiquitination	[2]
67	SDRAEEFKKLNCQVI	acetylation	[1]
109	IPLVSDPKRTIAQDY	acetylation	[1]
120	AQDYGVLKADEGISF	acetylation	[1]
136	GLFIIDDKGILRQIT	acetylation	[1]
197	KSKEYFSKQK*****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). 

Sequence Annotation

 DOMAIN 6 165 Thioredoxin.
 ACT_SITE 52 52 Cysteine sulfenic acid (-SOH)
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 7 7 N6-acetyllysine (By similarity).
 MOD_RES 16 16 N6-acetyllysine (By similarity).
 MOD_RES 27 27 N6-acetyllysine (By similarity).
 MOD_RES 35 35 N6-acetyllysine (By similarity).
 MOD_RES 90 90 Phosphothreonine (By similarity).
 DISULFID 52 52 Interchain (with C-173); in linked form.
 DISULFID 173 173 Interchain (with C-52); in linked form.  

Keyword

 3D-structure; Acetylation; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 199 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005759; C:mitochondrial matrix; IDA:RGD.
 GO:0005719; C:nuclear euchromatin; IDA:RGD.
 GO:0005730; C:nucleolus; IDA:RGD.
 GO:0005782; C:peroxisomal matrix; IDA:RGD.
 GO:0020037; F:heme binding; IPI:RGD.
 GO:0051920; F:peroxiredoxin activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0008379; F:thioredoxin peroxidase activity; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0034101; P:erythrocyte homeostasis; IEA:Compara.
 GO:0042744; P:hydrogen peroxide catabolic process; IEA:Compara.
 GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Compara.
 GO:0042345; P:regulation of NF-kappaB import into nucleus; IEA:Compara.
 GO:0032872; P:regulation of stress-activated MAPK cascade; IEA:Compara.
 GO:0019430; P:removal of superoxide radicals; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IDA:RGD. 

Interpro

 IPR000866; AhpC/TSA.
 IPR024706; Peroxiredoxin_AhpC-typ.
 IPR019479; Peroxiredoxin_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF10417; 1-cysPrx_C
 PF00578; AhpC-TSA 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS