UniProt Accession

 SL9A6_HUMAN; Q92581; A6NIQ9; A8K160; B4DU30; B7ZAE0; Q3ZCW7; Q5JPP8; Q5JPP9; Q86VS0 

Genbank Protein ID

 AF030409; AK289775; AK300475; AK316255; AL732579; AL732579; AL732579; BC035029; BC049169; D87743 

Genbank Nucleotide ID

 AAC39643.1; BAF82464.1; BAG62192.1; BAH14626.1; CAI39923.1; CAI39924.1; CAI39925.1; AAH35029.1; AAH49169.1; BAA13449.1 

Protein Name

 Sodium/hydrogen exchanger 6 

Protein Synonyms/Alias

 Na(+)/H(+) exchanger 6; NHE-6; Solute carrier family 9 member 6 

Gene Name

 SLC9A6 

Gene Synonyms/Alias

 KIAA0267; NHE6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
443	LNLGRRSKIGSNFQH	ubiquitination	[1, 2]
528	ENERRTTKAESAWLF	ubiquitination	[3, 4, 5, 6]

Reference

 [1] Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.
 Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D.
 Proteomics. 2007 Mar;7(6):868-74. [PMID: 17370265]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis. 

Sequence Annotation

 CARBOHYD 128 128 N-linked (GlcNAc...).
 CROSSLNK 443 443 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; Antiport; Complete proteome; Endosome; Epilepsy; Glycoprotein; Ion transport; Isopeptide bond; Membrane; Mental retardation; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 669 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
 GO:0015385; F:sodium:hydrogen antiporter activity; TAS:ProtInc.
 GO:0006885; P:regulation of pH; IEA:InterPro. 

Interpro

 IPR006153; Cation/H_exchanger.
 IPR018422; Cation/H_exchanger_CPA1.
 IPR002090; Na/H_exchanger_6.
 IPR004709; NaH_exchanger. 

Pfam

 PF00999; Na_H_Exchanger 

SMART

  

PROSITE

  

PRINTS

 PR01084; NAHEXCHNGR.
 PR01088; NAHEXCHNGR6.