| Tag | Content |
|---|
| CPLM ID | CPLM-016588 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium bicarbonate cotransporter 3 |
Protein Synonyms/Alias | Solute carrier family 4 member 7 |
Gene Name | Slc4a7 |
Gene Synonyms/Alias | Nbc3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 371 | IFHDVAYKAKDRNDL | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. |
Sequence Annotation | REGION 918 920 CA2-binding (By similarity).
MOTIF 1031 1034 PDZ-binding (By similarity).
MOD_RES 238 238 Phosphoserine.
MOD_RES 247 247 Phosphoserine.
MOD_RES 271 271 Phosphoserine (By similarity).
MOD_RES 275 275 Phosphoserine.
MOD_RES 951 951 Phosphothreonine.
MOD_RES 960 960 Phosphoserine.
MOD_RES 1033 1033 Phosphoserine.
CARBOHYD 176 176 N-linked (GlcNAc...) (Potential).
CARBOHYD 274 274 N-linked (GlcNAc...) (Potential).
CARBOHYD 644 644 N-linked (GlcNAc...) (Potential).
CARBOHYD 654 654 N-linked (GlcNAc...).
CARBOHYD 664 664 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Cell membrane; Cell projection; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1034 AA |
Protein Sequence | MEADGAGEQM RPLLTRGPDE EAVVDLGKTS STVNTKFEKE ELESHRAVYV GVHVPFSKES 60
RRRHKHRGHK HHHRRRKDKD SDKEDGRESP SYDTPSQRVQ FILGTEDDDE EHIPHDLFTE 120
MDELCYRDGE EYEWKETARW LKFEEDVEDG GDRWSKPYVA TLSLHSLFEL RSCILNGTVM 180
LDMRASTLDE IADMVLDNMI ASGQLDDSIR ENVREALLKR HHHQNEKRFT SRIPLVRSFA 240
DIGILASPQS APGNLDNSKS GEMKGNGSGG SRENSTVDFS KVDMNFMRKI PTGAEASNVL 300
VGEVDFLERP IIAFVRLAPA VLLSGLTEVP VPTRFLFLLL GPAGKAPQYH EIGRSIATLM 360
TDEIFHDVAY KAKDRNDLLS GIDEFLDQVT VLPPGEWDPS IRIEPPKSVP SQEKRKIPVF 420
PNGSAAMSVG PPKEDDHHAG PELQRTGRLF GGLILDIKRK APFFLSDFKD ALSLQCLASI 480
LFLYCACMSP VITFGGLLGE ATEGRISAIE SLFGASLTGI AYSLFAGQPL TILGSTGPVL 540
VFEKILFKFC RDYHLSYLSL RTSIGLWTSF LCIVLVATDA SSLVCYITRF TEEAFAALIC 600
IIFIYEALEK LFHLGEIYAF NMHNNLDELT SYTCVCAEPS NPSNETLELW KRKNITAYSV 660
SWGNLTVSEC KTFHGMFVGS ACGPHGPYVP DVLFWCVVLF FTTFFLSSFL KQFKTKGYFP 720
TKVRSTISDF AVFLTIVIMV AIDYLVGIPS PKLHVPEKFE PTDPSRGWII SPLGDNPWWT 780
LLIAAVPALL CTILIFMDQQ ITAVIINRKE HKLKFIPMPV LYGVFLYMGV SSLKGIQFFD 840
RIKLFGMPAK HQPDLIYLRY VPLWKVHVFT VVQLTCLVLL WVIKASAAAV VFPMMVLALV 900
FVRKLMDLCF TKRELSWLDD LMPESKKKKE DDKKKKEKEE AERMLQDDED TVHLPFERGS 960
LLQIPVKTLK YSIDPSVVNI SDEMAKTAQW KALSMNTENA KVTRPNTSPE KPVSVTINFE 1020
DEPSKKYMDA ETSL 1034 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IDA:UniProtKB. GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB. GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell. GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0060117; P:auditory receptor cell development; IMP:MGI. GO:0021747; P:cochlear nucleus development; IMP:MGI. GO:0061299; P:retina vasculature morphogenesis in camera-type eye; IMP:MGI. GO:0046666; P:retinal cell programmed cell death; IMP:MGI. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |