CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043138
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Proteasome subunit alpha type-4 
Protein Synonyms/Alias
  
Gene Name
 PSMA4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
198KTVIRVLKQKEVEQLubiquitination[1]
200VIRVLKQKEVEQLIKacetylation[2]
200VIRVLKQKEVEQLIKubiquitination[1, 2, 3, 4, 5]
207KEVEQLIKKHEEEEAacetylation[6]
207KEVEQLIKKHEEEEAubiquitination[1, 2, 3, 4, 5]
215KHEEEEAKAEREKKEubiquitination[4, 7]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 230 AA 
Protein Sequence
MSRRYDSRTT IFSPEAERRN IHKLLDEVFF SEKIYKLNED MACSVAGITS DANVLTNELR 60
LIAQRYLLQY QEPIPCEQLV TALCDIKQAY TQFGGKRPFG VSLLYIGWDK HYGFQLYQSD 120
PSGNYGGWKA TCIGNNSAAA VSMLKQDYKE GEMTLKSALA LAIKVLNKTM DVSKLSAEKV 180
EIATLTRENG KTVIRVLKQK EVEQLIKKHE EEEAKAEREK KEKEQKEKDK 230 
Gene Ontology
 GO:0005839; C:proteasome core complex; IEA:InterPro.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:InterPro.
 GO:0051603; P:proteolysis involved in cellular protein catabolic process; IEA:InterPro. 
Interpro
 IPR023332; Proteasome_suA-type.
 IPR001353; Proteasome_sua/b. 
Pfam
 PF00227; Proteasome 
SMART
  
PROSITE
 PS51475; PROTEASOME_A_2 
PRINTS