CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022249
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pleckstrin homology domain-containing family J member 1 
Protein Synonyms/Alias
 PH domain-containing family J member 1; Guanine nucleotide-releasing protein x 
Gene Name
 PLEKHJ1 
Gene Synonyms/Alias
 GNRPX 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
6**MRYNEKELQALSRubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 DOMAIN 15 108 PH.  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 149 AA 
Protein Sequence
MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT DEAEPVGALL 60
LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM EALRRASYEF MRRSLIFYRN 120
EIRKVTGKDP LEQFGISEEA RFQLSGLQA 149 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS50003; PH_DOMAIN 
PRINTS