CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039067
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pyrin 
Protein Synonyms/Alias
  
Gene Name
 Mefv 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
247KLPLTQKKENPQIQKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 747 AA 
Protein Sequence
MANTRVDHLL NTLEELLPYE LEKFKFKLHT TSLEKGHSRI PLSLVKMARP IKLTRLLLTY 60
YGEEYAVRLT LQILRATNQR QLAEELHKAT GPEHLTEENG VGGSVQSSAE NKDKGVKGSD 120
VPGEDEAQQN DDESDILPPI QAEVGKGPQK KSLAKRKDQR GPESLDSQTK PGARSAAPLY 180
RRTLVTQSPG DKENRAGAQP QECQLCREAA RSTAMSQGGE RSRRLKCICL QERSDPGVLK 240
LPLTQKKENP QIQKLFRLKR KQEMAVSFVR EATLNGRTTG TLEKGVGIPE HSMMLDEETS 300
RNMSSKISLT REKRCTASWT ENGNGGPETP ETLGETVSSI LCDSCSPKVL LSLGEKLAQT 360
PEDPASLGQA ASKGRSRDKV ACPLCHTQGE LPAKACVQSS CSCSVAPGDP KASGRHSICF 420
QCQSSRAGKS CEAQSPQFLP QCPRHMKQVQ LLFCEDHREP ICLICRLSQE HQGHRVRPIE 480
EAALQYKEQI RKQLERLREM RGYVEEHKLP ADKKAEDFLK QTETQKQRIS CPLEKLFQFL 540
EQQEQLFVTW LQELVQTIGK VRETYYTQVS LLDKLIGELE AKQDQPEWEL MQDIGATLHR 600
AETMTASELL GIPPGVKEKL HLLYQKSKSA EKNMQRFSEM LGSEMAFSAS DVATREGCRP 660
STTKAQALIP TVHLKCDGAH TQDFDVILCA ELEAGGSEPQ DYLHPSSAQD TPELHEIHSQ 720
NNKRKFKSFL KWKPSFSRTD RCLRTCW 747 
Gene Ontology
 GO:0005875; C:microtubule associated complex; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Compara.
 GO:0032695; P:negative regulation of interleukin-12 production; IEA:Compara.
 GO:0071641; P:negative regulation of macrophage inflammatory protein 1 alpha production; IEA:Compara.
 GO:2001056; P:positive regulation of cysteine-type endopeptidase activity; IEA:Compara. 
Interpro
 IPR004020; DAPIN.
 IPR011029; DEATH-like_dom.
 IPR000315; Znf_B-box. 
Pfam
 PF02758; PYRIN
 PF00643; zf-B_box 
SMART
 SM00336; BBOX 
PROSITE
 PS50824; DAPIN
 PS50119; ZF_BBOX 
PRINTS