UniProt Accession

 S10A6_RAT; P05964; Q9R2B7 

Genbank Protein ID

 AJ132717; AF140232 

Genbank Nucleotide ID

 CAB42002.1; AAK28306.1 

Protein Name

 Protein S100-A6 

Protein Synonyms/Alias

 Calcyclin; Prolactin receptor-associated protein; S100 calcium-binding protein A6 

Gene Name

 S100a6 

Gene Synonyms/Alias

 Cacy 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
22	IFHKYSGKEGDKHTL	acetylation	[1]
26	YSGKEGDKHTLSKKE	acetylation	[1]
35	TLSKKELKELIQKEL	acetylation	[1]
40	ELKELIQKELTIGAK	acetylation	[1]
47	KELTIGAKLQDAEIA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). Interacts with FKBP4 (By similarity). 

Sequence Annotation

 DOMAIN 12 47 EF-hand 1.
 DOMAIN 48 83 EF-hand 2.
 MOD_RES 40 40 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Calcium; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Metal-binding; Nucleus; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 89 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
 GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0015075; F:ion transmembrane transporter activity; IDA:RGD.
 GO:0008270; F:zinc ion binding; IEA:Compara. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001751; S100/CaBP-9k_CS.
 IPR013787; S100_Ca-bd_sub. 

Pfam

 PF01023; S_100 

SMART

  

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00303; S100_CABP 

PRINTS