CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009395
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 5 
Protein Synonyms/Alias
 BMP2-induced 3-kb gene protein; WD repeat-containing protein BIG-3 
Gene Name
 Wdr5 
Gene Synonyms/Alias
 Big; Big3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
6**MATEEKKPETEAAacetylation[1]
7*MATEEKKPETEAARacetylation[1]
27SSSATQSKPTPVKPNubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). 
Sequence Annotation
 REPEAT 43 82 WD 1.
 REPEAT 85 126 WD 2.
 REPEAT 128 168 WD 3.
 REPEAT 169 208 WD 4.
 REPEAT 212 253 WD 5.
 REPEAT 256 296 WD 6.
 REPEAT 299 333 WD 7.
 MOD_RES 112 112 N6-acetyllysine (By similarity).  
Keyword
 3D-structure; Acetylation; Chromatin regulator; Complete proteome; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 334 AA 
Protein Sequence
MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL 60
ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK 120
CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN 180
RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL 240
WDYSKGKCLK TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH 300
TDVVISTACH PTENIIASAA LENDKTIKLW KSDC 334 
Gene Ontology
 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:MGI.
 GO:0000123; C:histone acetyltransferase complex; ISS:UniProtKB.
 GO:0035097; C:histone methyltransferase complex; ISO:MGI.
 GO:0071339; C:MLL1 complex; ISS:UniProtKB.
 GO:0048188; C:Set1C/COMPASS complex; ISS:UniProtKB.
 GO:0046972; F:histone acetyltransferase activity (H4-K16 specific); IEA:Compara.
 GO:0043995; F:histone acetyltransferase activity (H4-K5 specific); IEA:Compara.
 GO:0043996; F:histone acetyltransferase activity (H4-K8 specific); IEA:Compara.
 GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IEA:Compara.
 GO:0035064; F:methylated histone residue binding; ISS:UniProtKB.
 GO:0043966; P:histone H3 acetylation; IEA:Compara.
 GO:0051568; P:histone H3-K4 methylation; ISS:UniProtKB.
 GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.
 GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
 GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0001501; P:skeletal system development; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.