| Tag | Content |
|---|
| CPLM ID | CPLM-019902 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-acylneuraminate cytidylyltransferase |
Protein Synonyms/Alias | CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase |
Gene Name | Cmas |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 39 | GAGRGLEKPPHLAAL | ubiquitination | [1] | | 54 | VLARGGSKGIPLKNI | ubiquitination | [1] | | 59 | GSKGIPLKNIKRLAG | ubiquitination | [1] | | 183 | FRWSEIQKGVREVTE | ubiquitination | [1] | | 329 | ISERACSKQTLSALK | ubiquitination | [1] | | 380 | VSDEECLKRVGLSAV | ubiquitination | [1] | | 404 | KAVGYICKCSGGRGA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). |
Sequence Annotation | MOTIF 15 31 BC1 motif.
MOTIF 198 204 BC2 motif.
MOTIF 267 274 BC3 motif.
ACT_SITE 199 199
BINDING 50 50 Substrate.
BINDING 60 60 Substrate.
BINDING 109 109 Substrate.
BINDING 118 118 Substrate.
BINDING 120 120 Substrate.
BINDING 141 141 Substrate.
MOD_RES 1 1 N-acetylmethionine (By similarity). |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Nucleotidyltransferase; Nucleus; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 432 AA |
Protein Sequence | MDALEKGAVT SGPAPRGRPS RGRPPKLQRS RGAGRGLEKP PHLAALVLAR GGSKGIPLKN 60
IKRLAGVPLI GWVLRAALDA GVFQSVWVST DHDEIENVAK QFGAQVHRRS SETSKDSSTS 120
LDAIVEFLNY HNEVDIVGNI QATSPCLHPT DLQKVAEMIR EEGYDSVFSV VRRHQFRWSE 180
IQKGVREVTE PLNLNPAKRP RRQDWDGELY ENGSFYFAKR HLIEMGYLQG GKMAYYEMRA 240
EHSVDIDVDI DWPIAEQRVL RFGYFGKEKL KEIKLLVCNI DGCLTNGHIY VSGDQKEIIS 300
YDVKDAIGIS LLKKSGIEVR LISERACSKQ TLSALKLDCK TEVSVSDKLA TVDEWRKEMG 360
LCWKEVAYLG NEVSDEECLK RVGLSAVPAD ACSGAQKAVG YICKCSGGRG AIREFAEHIF 420
LLIEKVNNSC QK 432 |
Gene Ontology | GO:0005634; C:nucleus; ISA:MGI. GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; ISA:MGI. GO:0006055; P:CMP-N-acetylneuraminate biosynthetic process; ISA:MGI. GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro. GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |