| Tag | Content |
|---|
| CPLM ID | CPLM-006374 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Guanine-nucleotide exchange factor YEL1 |
Protein Synonyms/Alias | EFA6-like protein 1 |
Gene Name | YEL1 |
Gene Synonyms/Alias | YBL060W; YBL0507; YBL0517 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 36 | EGVLHGSKSMPTSMK | ubiquitination | [1] | | 286 | SDNQSSLKRFSTLGS | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Guanine-nucleotide exchange factor for ARF3 required for localization of ARF3 to the bud neck and tip and involved in actin patch polarization. |
Sequence Annotation | DOMAIN 61 266 SEC7.
DOMAIN 412 551 PH.
MOD_RES 290 290 Phosphothreonine.
MOD_RES 293 293 Phosphoserine.
MOD_RES 299 299 Phosphoserine. |
Keyword | Cell membrane; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 687 AA |
Protein Sequence | MCASLNEVKK NDTYGVSQKG YNDNFSESEG VLHGSKSMPT SMKNMLQSPT MVNMCDILQN 60
KEAANDEKPV IPTTDTATAG TGTEDISSTQ SEETDQNSHL IASEILEGTF KDVSYKEYAN 120
FLGNDNNNQV LTEFVKLLSP LPSSLLETLF NLSKSIYFIA EAQNIDRILE CLSIEWIACH 180
PNTHWKSGYK SCHIVLFSLL ILNSDLHNNF QVDHKKIKFS MVAFINNTLR ALREENEYEE 240
LKIYSREHLI IEELSEYYKT LNETPLPLCT ESRTSINISD NQSSLKRFST LGSREFSTSN 300
LRSVNSNSTT LYSRDGQVSV REMSAKSNKN FHNNHPMDAL YLKESFDDGL ITENGSSWFM 360
DDLILISKKS LPRKYSKRDK DQVAAPKMTS KRNKSFFGWL KPSKTTTLIE HTSRRTSLSY 420
LNKDSEWERV KIQVKEGRIF IFKIKPDVKD IIQSSETDSA TIDYFKDISS SYFAYSLLEA 480
EAHVVQDNII IGSGAMKSNV CNKNTKRKSG NFTVSFPENI NGPKLVLEFQ TRSVEEAHKF 540
MDCINFWAGR ISPVPLTQFE AVSNAEYGWS DKILTEHASL NLKNIVVSEW KPLLGLELLY 600
EDAKDVEMVE LKERLKELMN FTRQLGIWID KHNEIKDKLV EIWSFDDNYF EAVMNNWNSR 660
YLYMNNQYKK RLSYLKALQK AMGSVQF 687 |
Gene Ontology | GO:0005935; C:cellular bud neck; IDA:SGD. GO:0005934; C:cellular bud tip; IDA:SGD. GO:0005737; C:cytoplasm; IDA:SGD. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IDA:SGD. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0051666; P:actin cortical patch localization; IMP:SGD. GO:0010513; P:positive regulation of phosphatidylinositol biosynthetic process; IMP:SGD. GO:0008104; P:protein localization; IMP:SGD. GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |