CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000775
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Unconventional myosin-Ib 
Protein Synonyms/Alias
 MYH-1c; Myosin I alpha; MMI-alpha; MMIa 
Gene Name
 MYO1B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
139GAEVNQVKEQLLQSNubiquitination[1]
156LEAFGNAKTVRNDNSubiquitination[1]
241YLSLDSAKVNGVDDAubiquitination[1]
588LMKNLQTKNPNYIRCubiquitination[1]
914GAYLEINKNPKYKKLubiquitination[1]
928LKDAIEEKIIIAEVVubiquitination[1]
1028RTTLSQTKQKLNIEIubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport (By similarity). 
Sequence Annotation
 DOMAIN 17 688 Myosin head-like.
 DOMAIN 704 733 IQ 1.
 DOMAIN 728 748 IQ 2.
 DOMAIN 750 779 IQ 3.
 DOMAIN 779 808 IQ 4.
 DOMAIN 808 837 IQ 5.
 DOMAIN 837 866 IQ 6.  
Keyword
 Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1136 AA 
Protein Sequence
MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS VVISVNPYRS 60
LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK DQCILITGES GAGKTEASKL 120
VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP 180
LGGVISNYLL EKSRVVKQPR GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA 240
KVNGVDDAAN FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI 300
KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD ALAKNLYSRL 360
FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE QFIINYCNEK LQQIFIELTL 420
KEEQEEYIRE DIEWTHIDYF NNAIICDLIE NNTNGILAML DEECLRPGTV TDETFLEKLN 480
QVCATHQHFE SRMSKCSRFL NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ 540
AMWKASHALI KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND 600
KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK QTWPHWKGPA 660
RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR KQRLEDLATL IQKIYRGWKC 720
RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT KSSALVIQSY IRGWKARKIL RELKHQKRCK 780
EAVTTIAAYW HGTQVRREYR KFFRANAGKK IYEFTLQRIV QKYFLEMKNK MPSLSPIDKN 840
WPSRPYLFLD STHKELKRIF HLWRCKKYRD QFTDQQKLIY EEKLEASELF KDKKALYPSS 900
VGQPFQGAYL EINKNPKYKK LKDAIEEKII IAEVVNKINR ANGKSTSRIF LLTNNNLLLA 960
DQKSGQIKSE VPLVDVTKVS MSSQNDGFFA VHLKEGSEAA SKGDFLFSSD HLIEMATKLY 1020
RTTLSQTKQK LNIEISDEFL VQFRQDKVCV KFIQGNQKNG SVPTCKRKNN RLLEVAVP 1078 
Gene Ontology
 GO:0005903; C:brush border; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0030175; C:filopodium; ISS:UniProtKB.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0000146; F:microfilament motor activity; ISS:UniProtKB.
 GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISS:UniProtKB.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB.
 GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
 GO:0030048; P:actin filament-based movement; ISS:UniProtKB. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR010926; Myosin_tail_2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00612; IQ
 PF00063; Myosin_head
 PF06017; Myosin_TH1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.