UniProt Accession

 SWI6_SCHPO; P40381 

Genbank Protein ID

 X71783; CU329670 

Genbank Nucleotide ID

 CAA50668.1; CAB57340.1 

Protein Name

 Chromatin-associated protein swi6 

Protein Synonyms/Alias

  

Gene Name

 swi6 

Gene Synonyms/Alias

 SPAC664.01c; SPAC824.10c 

Created Date

 July 27, 2013 

Organism

 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 

NCBI Taxa ID

 284812 

Lysine Modification

Position	Peptide	Type	References
103	GGYEYLLKWEGYDDP	sumoylation	[1]

Reference

 [1] SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast.
 Shin JA, Choi ES, Kim HS, Ho JC, Watts FZ, Park SD, Jang YK.
 Mol Cell. 2005 Sep 16;19(6):817-28. [PMID: 16168376] 

Functional Description

 Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Involved in the repression of the silent mating-type loci MAT2 and MAT3. May compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes. 

Sequence Annotation

 DOMAIN 81 143 Chromo 1.
 DOMAIN 267 328 Chromo 2.
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 220 220 Phosphoserine.
 MOD_RES 227 227 Phosphoserine.
 MOD_RES 240 240 Phosphothreonine.
 MOD_RES 246 246 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 328 AA 

Protein Sequence

Gene Ontology

 GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.
 GO:0044732; C:mitotic spindle pole body; IDA:PomBase.
 GO:0031618; C:nuclear centromeric heterochromatin; IDA:PomBase.
 GO:0005724; C:nuclear telomeric heterochromatin; IDA:PomBase.
 GO:0006338; P:chromatin remodeling; NAS:PomBase.
 GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.
 GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:PomBase.
 GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.
 GO:0072356; P:chromosome passenger complex localization to kinetochore; NAS:PomBase.
 GO:0007535; P:donor selection; IMP:PomBase.
 GO:0071459; P:protein localization to chromosome, centromeric region; IMP:PomBase.
 GO:0007062; P:sister chromatid cohesion; IGI:PomBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR023780; Chromo_domain.
 IPR000953; Chromo_domain/shadow.
 IPR008251; Chromo_shadow_dom.
 IPR016197; Chromodomain-like.
 IPR023779; Chromodomain_CS. 

Pfam

 PF00385; Chromo
 PF01393; Chromo_shadow 

SMART

 SM00298; CHROMO
 SM00300; ChSh 

PROSITE

 PS00598; CHROMO_1
 PS50013; CHROMO_2 

PRINTS