UniProt Accession

 RL10_HUMAN; P27635; A3KQT0; D3DWW6; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5 

Genbank Protein ID

 M64241; M81806; M73791; S64169; S64168; AF486812; DQ369703; DQ369704; DQ369705; DQ369706; DQ369707; DQ369708; DQ369709; DQ369710; DQ369711; DQ369712; DQ369713; DQ369714; DQ369715; DQ369716; CR456797; CR542069; AK223309; L44140; BX936347; BX936346; BX936346; BX936347; BX936347; BX936346; BX936346; BX936347; CH471172; CH471172; BC003358; BC026276; BC071918; S35960; AB007170 

Genbank Nucleotide ID

 AAA63253.1; AAA36021.1; AAA36378.1; AAB27665.1; AAB27665.1; AAL88713.1; ABC88559.1; ABC88560.1; ABC88561.1; ABC88562.1; ABC88563.1; ABC88564.1; ABC88565.1; ABC88566.1; ABC88567.1; ABC88568.1; ABC88569.1; ABC88570.1; ABC88571.1; ABC88572.1; CAG33078.1; CAG46866.1; BAD97029.1; AAA92646.1; CAI43214.1; CAI43214.1; CAI43230.1; CAI43230.1; CAM45852.1; CAM45852.1; CAM45853.1; CAM45853.1; EAW72737.1; EAW72739.1; AAH03358.1; AAH26276.1; AAH71918.1; AAB22173.1; BAA28595.1 

Protein Name

 60S ribosomal protein L10 

Protein Synonyms/Alias

 Laminin receptor homolog; Protein QM; Tumor suppressor QM 

Gene Name

 RPL10 

Gene Synonyms/Alias

 DXS648E; QM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	CRGVPDAKIRIFDLG	ubiquitination	[1, 2]
42	DLGRKKAKVDEFPLC	ubiquitination	[2, 3]
74	AARICANKYMVKSCG	ubiquitination	[1, 2, 4]
78	CANKYMVKSCGKDGF	ubiquitination	[2]
82	YMVKSCGKDGFHIRV	ubiquitination	[2, 4]
101	FHVIRINKMLSCAGA	ubiquitination	[1, 2, 4]
121	GMRGAFGKPQGTVAR	acetylation	[5]
121	GMRGAFGKPQGTVAR	ubiquitination	[1, 2, 3, 4, 6]
145	IRTKLQNKEHVIEAL	ubiquitination	[1, 2, 3]
156	IEALRRAKFKFPGRQ	ubiquitination	[2]
170	QKIHISKKWGFTKFN	ubiquitination	[2]
175	SKKWGFTKFNADEFE	ubiquitination	[1, 2, 3, 4]
188	FEDMVAEKRLIPDGC	ubiquitination	[2, 3, 4, 6, 7, 8]
208	PNRGPLDKWRALHS*	acetylation	[5, 9]
208	PNRGPLDKWRALHS*	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [6] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [7] Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
 Meierhofer D, Wang X, Huang L, Kaiser P.
 J Proteome Res. 2008 Oct;7(10):4566-76. [PMID: 18781797]
 [8] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [9] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 

Functional Description

  

Sequence Annotation

 CROSSLNK 188 188 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Isopeptide bond; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 214 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
 GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR001197; Ribosomal_L10e.
 IPR016180; Ribosomal_L10e/L16.
 IPR018255; Ribosomal_L10e_CS. 

Pfam

 PF00252; Ribosomal_L16 

SMART

  

PROSITE

 PS01257; RIBOSOMAL_L10E 

PRINTS