UniProt Accession

 DECR2_RAT; Q9Z2M4 

Genbank Protein ID

 AF044574; BC070959 

Genbank Nucleotide ID

 AAD02333.1; AAH70959.1 

Protein Name

 Peroxisomal 2,4-dienoyl-CoA reductase 

Protein Synonyms/Alias

 2,4-dienoyl-CoA reductase 2; DCR-AKL; pVI-AKL 

Gene Name

 Decr2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
102	AAVDQALKEFGKIDI	acetylation	[1]
230	PKASSKFKYLSSPIP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19- docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. 

Sequence Annotation

 NP_BIND 35 40 NADP (By similarity).
 NP_BIND 60 64 NADP (By similarity).
 NP_BIND 208 214 NADP (By similarity).
 REGION 126 128 Substrate binding (By similarity).
 MOTIF 290 292 Microbody targeting signal.
 BINDING 60 60 Substrate (By similarity).
 BINDING 86 86 NADP (By similarity).
 BINDING 88 88 Substrate (By similarity).
 BINDING 118 118 Substrate (By similarity).
 BINDING 182 182 NADP (By similarity).
 BINDING 219 219 Substrate (By similarity).
 MOD_RES 151 151 N6-acetyllysine (By similarity).
 MOD_RES 291 291 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Fatty acid metabolism; Lipid metabolism; NADP; Oxidoreductase; Peroxisome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
 GO:0008670; F:2,4-dienoyl-CoA reductase (NADPH) activity; IDA:UniProtKB.
 GO:0019166; F:trans-2-enoyl-CoA reductase (NADPH) activity; IEA:Compara.
 GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:Compara. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.