CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022549
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynein heavy chain 1, axonemal 
Protein Synonyms/Alias
 Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1; Heat shock regulated protein 1; HSRF-1; hDHC7 
Gene Name
 DNAH1 
Gene Synonyms/Alias
 DHC7; DNAHC1; KIAA1410 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1055IDAEQLEKNVVEAFKubiquitination[1]
1164AIEQALDKMEKEWSTmethylation[2]
1844DVEGFLTKCIQLYETacetylation[3]
2057SFVRSSVKEVIASTNubiquitination[1]
2073NLTMSLLKLLDCFFKubiquitination[1]
2080KLLDCFFKPFLPREGubiquitination[1]
2494SWFDQLLKRCMEQWEubiquitination[1]
2949QRPPPGVKLVIEAVCubiquitination[1]
2959IEAVCIMKGIKPKKVubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). 
Sequence Annotation
 NP_BIND 1581 1588 ATP (Potential).
 NP_BIND 1862 1869 ATP (Potential).
 NP_BIND 2227 2234 ATP (Potential).
 NP_BIND 2586 2593 ATP (Potential).
 REGION 1 1542 Stem (By similarity).
 REGION 1543 1764 AAA 1 (By similarity).
 REGION 1824 2057 AAA 2 (By similarity).
 REGION 2189 2449 AAA 3 (By similarity).
 REGION 2547 2799 AAA 4 (By similarity).
 REGION 2814 3112 Stalk (By similarity).
 REGION 3262 3492 AAA 5 (By similarity).
 REGION 3705 3924 AAA 6 (By similarity).
 MOTIF 1581 1588 GPAGTGKT motif.
 MOTIF 1631 1637 CFDEFNR motif.  
Keyword
 Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein; Nucleotide-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4330 AA 
Protein Sequence
MEQPNSKGYS LGRTPQGPEC SSAPAVQVGT HRGLEYNPGK ILPGSDYGLG NPPALDPKLP 60
HLPLPPAPPT LSDLGQPRKS PLTGTDKKYP LMKQRGFYSD ILSPGTLDQL GEVCRGPRMS 120
QNLLRQADLD KFTPRVGSFE VPEDFQERME QQCIGSTTRL LAQTDFPLQA YEPKMQVPFQ 180
VLPGQHPRKI EIERRKQQYL SLDIEQLLFS QGIDSNKLMP RHLDHQHPQT IEQGHDPIFP 240
IYLPLKVFDN EDFDCRTPRE WINMGLEPGS LDRKPVPGKA LLPTDDFLGH EDPKSQKLKY 300
KWCEVGVLDY DEEKKLYLVH KTDEKGLVRD EMGRPILNAG VTTEGRPPLQ VCQYWVPRIQ 360
LLFCAEDPCM FAQRVVQANA LRKNTEALLL YNLYVDCMPS DGQHVISEQS LSKIKQWALS 420
TPRMRKGPSV LEHLSSLARE VSLDYERSMN KINFDHVVSS KPETFSYVTL PKKEEEQVPE 480
RGLVSVPKYH FWEQKEDFTF VSLLTRPEVI TALSKVRAEC NKVTAMSLFH SSLSKYSHLE 540
EFEQIQSQTF SQVQMFLKDS WISSLKVAMR SSLRDMSKGW YNLYETNWEV YLMSKLRKLM 600
ELVKYMLQDT LRFLVQDSLA SFSQFISDTC CSVLNCTDDM VWGDDLINSP YRPRKNPLFI 660
MDLVLDSSGV HYSTPLEQFE ASLLNLFDKG ILATHAVPQL EKLVMEDIFI SGDPLLESVG 720
LHEPLVEELR ATIASAVSKA MIPLQAYAKE YRKYLELNNN DIASFLKTYQ TQGLLAQEVR 780
EVVLTHLREK EILDSSLPSS IIIGPFYINT DNVKQSLSKK RKALATSVLD ILAKNLHKEV 840
DSICEEFRSI SRKIYEKPNS IEELAELREW MKGIPERLVG LEERIVKVMD DYQVMDEFLY 900
NLSSDDFNDK WIASNWPSKI LGQIELVQQQ HVEDEEKFRK IQIMDQNNFQ EKLEGLQLVV 960
AGFSIHVEIS RAHEIANEVR RVKKQLKDCQ QLAMLYNNRE RIFSLPITNY DKLSRMVKEF 1020
QPYLDLWTTA SDWLRWSESW MNDPLSAIDA EQLEKNVVEA FKTMHKCVKQ FKDMPACQEV 1080
ALDIRARIEE FKPYIPLIQG LRNPGMRIRH WETLSNQINI NVRPKANLTF ARCLEMNLQD 1140
HIESISKVAE VAGKEYAIEQ ALDKMEKEWS TILFNVLPYK ATDTYILKSP DEASQLLDDH 1200
IVMTQNMSFS PYKKPFEQRI NSWENKLKLT QEVLEEWLNC QRSWLYLEPI FSSEDINQQL 1260
PVESKRYQTM ERIWKKIMKN AYENREVINV CSDLRMLDSL RDCNKILDLV QKGLSEYLET 1320
KRSAFPRFYF LSDDELLEIL SQTKDPTAVQ PHLRKCFENI ARLLFQEDLE ITHMYSAEGE 1380
EVQLCFSIYP SSNVEDWLRE VERSMKASVH DIIEKAIRAY PTMPRTQWVL NWPGQVTIAG 1440
CQTYWTMEVA EALEAGNLRS QLFPQLCQQL SDLVALVRGK LSRMQRAVLS ALIVIEVHAK 1500
DVVSKLIQEN VVSVNDFQWI SQLRYYWTNN DLYIRAVNAE FIYGYEYLGN SGRLVITPLT 1560
DRCYLTLTGA LHLKFGGAPA GPAGTGKTET TKDLGKALAI QTVVFNCSDQ LDFMAMGKFF 1620
KGLASAGAWA CFDEFNRIDI EVLSVVAQQI TTIQKAQQQR VERFMFEGVE IPLVPSCAVF 1680
ITMNPGYAGR TELPDNLKAL FRPVAMMVPD YAMITEISLY SFGFNEASVL AKKITTTFKL 1740
SSEQLSSQDH YDFGMRAVKT VISAAGNLKR ENPSMNEELI CLRAIRDVNV PKFLQEDLKL 1800
FSGIVSDLFP TIKEEDTDYG ILDEAIREAC RNSNLKDVEG FLTKCIQLYE TTVVRHGLML 1860
VGPTGSGKST CYRVLAAAMT SLKGQPSISG GMYEAVNYYV LNPKSITMGQ LYGEFDLLTH 1920
EWTDGIFSSF IRAGAITSDT NKKWYMFDGP VDAIWIENMN TVLDDNKKLC LSSGEIIKLT 1980
EAMTMMFEVQ DLAVASPATV SRCGMVYLEP SILGLMPFIE CWLRKLPPLL KPYEEHFKAL 2040
FVSFLEESIS FVRSSVKEVI ASTNCNLTMS LLKLLDCFFK PFLPREGLKK IPSEKLSRIV 2100
ELIEPWFIFS LIWSVGATGD SSGRTSFSHW LRLKMENEQL TLLFPEEGLV FDYRLEDAGI 2160
SGTNDSEDEE EEYKQVAWVK WMDSSAPFTM VPDTNYCNII VPTMDTVQMS HLLDMLLTNK 2220
KPVLCIGPTG TGKTLTISDK LLKNLALDYI SHFLTFSART SANQTQDFID SKLDKRRKGV 2280
FGPPLGRNFI FFIDDLNMPA LETYGAQPPI ELLRQWMDHG GWYDRKIIGA FKNLVDINFV 2340
CAMGPPGGGR NTVTPRLMRH FNYLSFAEMD EVSKKRIFST ILGNWLDGLL GEKSYRERVP 2400
GAPHIAHFTE PLVEATIMVY ATITSQLLPT PAKSHYTFNL RDLSKVFQGM LMADPAKVED 2460
QVQLLRLWYH ENCRVFRDRL VNEEDRSWFD QLLKRCMEQW EVTFNKVCPF QPILYGDFMS 2520
PGSDVKSYEL ITSESKMMQV IEEYIEDYNQ INTAKLKLVL FMDAMSHICR ISRTLRQALG 2580
NALLLGVGGS GRSSLTRLAS HMAEYECFQI ELSKNYGMSE WRDDVKKVLL KAGLQNLPIT 2640
FLFSDTQIKN ESFLEDINNV LNSGDIPNLY TADEQDQIVS TMRPYIQEQG LQPTKANLMA 2700
AYTGRVRSNI HMVLCMSPIG EVFRARLRQF PSLVNCCTID WFNEWPAEAL KSVATVFLNE 2760
IPELESSQEE IQGLIQVCVY IHQSVSKKCI EYLAELTRHN YVTPKSYLEL LHIFSILIGQ 2820
KKLELKTAKN RMKSGLDKLL RTSEDVAKMQ EDLESMHPLL EEAAKDTMLT MEQIKVDTAI 2880
AEETRNSVQT EEIKANEKAK KAQAIADDAQ KDLDEALPAL DAALASLRNL NKNDVTEVRA 2940
MQRPPPGVKL VIEAVCIMKG IKPKKVPGEK PGTKVDDYWE PGKGLLQDPG HFLESLFKFD 3000
KDNIGDVVIK AIQPYIDNEE FQPATIAKVS KACTSICQWV RAMHKYHFVA KAVEPKRQAL 3060
LEAQDDLGVT QRILDEAKQR LREVEDGIAT MQAKYRECIT KKEELELKCE QCEQRLGRAG 3120
KVRTLLLQGL QAGPAQTGAR KDQGAGGSWG GCPHPLPGNP GATVGRASPR PLAQPPRAHP 3180
TGLPLQLING LSDEKVRWQE TVENLQYMLN NISGDVLVAA GFVAYLGPFT GQYRTVLYDS 3240
WVKQLRSHNV PHTSEPTLIG TLGNPVKIRS WQIAGLPNDT LSVENGVINQ FSQRWTHFID 3300
PQSQANKWIK NMEKDNGLDV FKLSDRDFLR SMENAIRFGK PCLLENVGEE LDPALEPVLL 3360
KQTYKQQGNT VLKLGDTVIP YHEDFRMYIT TKLPNPHYTP EISTKLTLIN FTLSPSGLED 3420
QLLGQVVAEE RPDLEEAKNQ LIISNAKMRQ ELKDIEDQIL YRLSSSEGNP VDDMELIKVL 3480
EASKMKAAEI QAKVRIAEQT EKDIDLTRME YIPVAIRTQI LFFCVSDLAN VDPMYQYSLE 3540
WFLNIFLSGI ANSERADNLK KRISNINRYL TYSLYSNVCR SLFEKHKLMF AFLLCVRIMM 3600
NEGKINQSEW RYLLSGGSIS IMTENPAPDW LSDRAWRDIL ALSNLPTFSS FSSDFVKHLS 3660
EFRVIFDSLE PHREPLPGIW DQYLDQFQKL LVLRCLRGDK VTNAMQDFVA TNLEPRFIEP 3720
QTANLSVVFK DSNSTTPLIF VLSPGTDPAA DLYKFAEEMK FSKKLSAISL GQGQGPRAEA 3780
MMRSSIERGK WVFFQNCHLA PSWMPALERL IEHINPDKVH RDFRLWLTSL PSNKFPVSIL 3840
QNGSKMTIEP PRGVRANLLK SYSSLGEDFL NSCHKVMEFK SLLLSLCLFH GNALERHKFG 3900
PLGFNIPYEF TDGDLRICIS QLKMFLDEYD DIPYKVLKYT AGEINYGGRV TDDWDRRCIM 3960
NILEDFYNPD VLSPEHSYSA SGIYHQIPPT YDLHGYLSYI KSLPLNDMPE IFGLHDNANI 4020
TFAQNETFAL LGTIIQLQPK SSSAGSQGRE EIVEDVTQNI LLKVPEPINL QWVMAKYPVL 4080
YEESMNTVLV QEVIRYNRLL QVITQTLQDL LKALKGLVVM SSQLELMAAS LYNNTVPELW 4140
SAKAYPSLKP LSSWVMDLLQ RLDFLQAWIQ DGIPAVFWIS GFFFPQAFLT GTLQNFARKF 4200
VISIDTISFD FKVMFEAPSE LTQRPQVGCY IHGLFLEGAR WDPEAFQLAE SQPKELYTEM 4260
AVIWLLPTPN RKAQDQDFYL CPIYKTLTRA GTLSTTGHST NYVIAVEIPT HQPQRHWIKR 4320
GVALICALDY 4330 
Gene Ontology
 GO:0005858; C:axonemal dynein complex; NAS:UniProtKB.
 GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003777; F:microtubule motor activity; NAS:UniProtKB.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0001539; P:ciliary or flagellar motility; NAS:UniProtKB.
 GO:0007018; P:microtubule-based movement; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; NAS:UniProtKB. 
Interpro
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR026983; DHC_fam.
 IPR026975; DNAH1.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07728; AAA_5
 PF12780; AAA_8
 PF08393; DHC_N2
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
  
PROSITE
  
PRINTS