CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038638
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Arachidonate 5-lipoxygenase 
Protein Synonyms/Alias
  
Gene Name
 Alox5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
456LCFPEAIKARGMDSTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 617 AA 
Protein Sequence
MPSYTVTVAT GSQWFAGTDD YIYLSLIGSA GCSEKHLLDK AFYNDFERGA VDSYDVTVDE 60
ELGEIYLVKI EKRKYWLHDD WYLKYITLKT PHGDYIEFPC YRWITGEGEI VLRDGRAKLA 120
RDDQIHILKQ HRRKELEARQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL 180
NYSKAMENLF INRFMHMFQS SWHDFADFEK IFVKISNTIS ERVKNHWQED LMFGYQFLNG 240
CNPVLIKRCT ALPPKLPVTT EMVECSLERQ LSLEQEVQEG NIFIVDYELL DGIDANKTDP 300
CTHQFLAAPI CLLYKNLANK IVPIAIQLNQ TPGESNPIFL PTDSKYDWLL AKIWVRSSDF 360
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPLFKLLVAH VRFTIAINTK AREQLICEYG 420
LFDKANATGG GGHVQMVQRA VQDLTYSSLC FPEAIKARGM DSTEDIPFYF YRDDGLLVWE 480
AIQSFTMEVV SIYYENDQVV EEDQELQDFV KDVYVYGMRG KKASGFPKSI KSREKLSEYL 540
TVVIFTASAQ HAAVNFGQLF LGMYPEEHFI EKPVKEAMIR FRKNLEAIVS VIAERNKNKK 600
LPYYYLSPDR IPNSVAI 617 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016165; F:lipoxygenase activity; IEA:InterPro.
 GO:0019370; P:leukotriene biosynthetic process; IDA:MGI.
 GO:0002540; P:leukotriene production involved in inflammatory response; IMP:MGI. 
Interpro
 IPR008976; Lipase_LipOase.
 IPR000907; LipOase.
 IPR013819; LipOase_C.
 IPR020834; LipOase_CS.
 IPR020833; LipOase_Fe_BS.
 IPR001024; LipOase_LH2.
 IPR001885; LipOase_mml. 
Pfam
 PF00305; Lipoxygenase
 PF01477; PLAT 
SMART
 SM00308; LH2 
PROSITE
 PS00711; LIPOXYGENASE_1
 PS00081; LIPOXYGENASE_2
 PS51393; LIPOXYGENASE_3
 PS50095; PLAT 
PRINTS
 PR00087; LIPOXYGENASE.
 PR00467; MAMLPOXGNASE.