UniProt Accession

 CNBP1_HUMAN; Q9NSA3; Q5T4V2 

Genbank Protein ID

 AB021262; AL357140; CH471130; BC014300; BC146892; BC146896 

Genbank Nucleotide ID

 BAB03458.1; CAI16886.1; EAW71631.1; AAH14300.1; AAI46893.1; AAI46897.1 

Protein Name

 Beta-catenin-interacting protein 1 

Protein Synonyms/Alias

 Inhibitor of beta-catenin and Tcf-4 

Gene Name

 CTNNBIP1 

Gene Synonyms/Alias

 ICAT 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
9	NREGAPGKSPEEMYI	ubiquitination	[1, 2]
19	EEMYIQQKVRVLLML	ubiquitination	[2, 3, 4]
28	RVLLMLRKMGSNLTA	ubiquitination	[1, 5]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 81 AA 

Protein Sequence

Gene Ontology

 GO:0030877; C:beta-catenin destruction complex; IDA:BHF-UCL.
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0009952; P:anterior/posterior pattern specification; IBA:RefGenome.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IBA:RefGenome.
 GO:0043392; P:negative regulation of DNA binding; IEA:Compara.
 GO:0072201; P:negative regulation of mesenchymal cell proliferation; IMP:BHF-UCL.
 GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0060633; P:negative regulation of transcription initiation from RNA polymerase II promoter; IEA:Compara.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IBA:RefGenome.
 GO:0045657; P:positive regulation of monocyte differentiation; IMP:BHF-UCL.
 GO:0045669; P:positive regulation of osteoblast differentiation; IMP:BHF-UCL.
 GO:0002528; P:regulation of vascular permeability involved in acute inflammatory response; IMP:BHF-UCL.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR009428; ICAT. 

Pfam

 PF06384; ICAT 

SMART

  

PROSITE

  

PRINTS