UniProt Accession

 H17B6_HUMAN; O14756; O43275 

Genbank Protein ID

 U89281; AF016509; AF223225; BC020710 

Genbank Nucleotide ID

 AAB88252.1; AAB67236.1; AAF81017.1; AAH20710.1 

Protein Name

 17-beta-hydroxysteroid dehydrogenase type 6 

Protein Synonyms/Alias

 17-beta-HSD 6; 17-beta-HSD6; 3-alpha->beta-hydroxysteroid epimerase; 3-alpha->beta-HSE; Oxidative 3-alpha hydroxysteroid dehydrogenase 

Gene Name

 HSD17B6 

Gene Synonyms/Alias

 RODH 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
64	LAACLTEKGAEQLRG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. 

Sequence Annotation

 NP_BIND 33 57 NAD (By similarity).
 ACT_SITE 176 176 Proton acceptor (By similarity).
 BINDING 164 164 Substrate (Potential).
 CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).
 CARBOHYD 215 215 N-linked (GlcNAc...) (Potential).
 CARBOHYD 256 256 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Endoplasmic reticulum; Endosome; Glycoprotein; Lipid metabolism; Membrane; Microsome; NAD; Oxidoreductase; Reference proteome; Signal; Steroid metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; NAS:UniProtKB.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IEA:EC.
 GO:0016491; F:oxidoreductase activity; NAS:UniProtKB.
 GO:0004745; F:retinol dehydrogenase activity; IEA:EC.
 GO:0047035; F:testosterone dehydrogenase (NAD+) activity; IEA:EC.
 GO:0006702; P:androgen biosynthetic process; NAS:UniProtKB.
 GO:0006710; P:androgen catabolic process; TAS:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.