CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035925
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho-related BTB domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 RHOBTB3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
111IKYNVNDKFSFHEVKubiquitination[1]
126DNYIPVIKRALNSVPubiquitination[1, 2, 3, 4, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 181 AA 
Protein Sequence
MRKRQTWSIH IVALGNEGDT FHQDNRPSGL IRTYLGRSPL VSGDESSLLL NAASTVARPV 60
FTEYQASAFG NVKLVVHDCP VWDIFDSDWY TSRNLIGGAD IIVIKYNVND KFSFHEVKDN 120
YIPVIKRALN SVPVIIAAVG TRQNEELPCT CPLCTSDRGS CVSTTEGIQL AKELGATYLE 180
L 181 
Gene Ontology
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR001806; Small_GTPase. 
Pfam
 PF00071; Ras 
SMART
  
PROSITE
  
PRINTS