CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007456
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-binding protein inhibitor ID-1 
Protein Synonyms/Alias
 Class B basic helix-loop-helix protein 24; bHLHb24; Inhibitor of DNA binding 1 
Gene Name
 ID1 
Gene Synonyms/Alias
 BHLHB24; ID 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23SCALKAGKTASGAGEubiquitination[1]
77NGCYSRLKELVPTLPubiquitination[1]
91PQNRKVSKVEILQHVubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. 
Sequence Annotation
 DOMAIN 53 105 bHLH.
 MOTIF 98 111 Nuclear export signal (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 155 AA 
Protein Sequence
MKVASGSTAT AAAGPSCALK AGKTASGAGE VVRCLSEQSV AISRCAGGAG ARLPALLDEQ 60
QVNVLLYDMN GCYSRLKELV PTLPQNRKVS KVEILQHVID YIRDLQLELN SESEVGTPGG 120
RGLPVRAPLS TLNGEISALT AEVRSRSDH 149 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IC:GDB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0001525; P:angiogenesis; TAS:BHF-UCL.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0043534; P:blood vessel endothelial cell migration; TAS:BHF-UCL.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0032963; P:collagen metabolic process; IEA:Compara.
 GO:0001886; P:endothelial cell morphogenesis; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0060425; P:lung morphogenesis; IEA:Compara.
 GO:0060426; P:lung vasculature development; IEA:Compara.
 GO:0043392; P:negative regulation of DNA binding; IEA:Compara.
 GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Compara.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:GDB.
 GO:0010621; P:negative regulation of transcription by transcription factor localization; TAS:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0031648; P:protein destabilization; IEA:Compara.
 GO:0045765; P:regulation of angiogenesis; IEA:Compara.
 GO:0043408; P:regulation of MAPK cascade; IEA:Compara.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:BHF-UCL. 
Interpro
 IPR011598; bHLH_dom.
 IPR026052; DNA-bd_prot-inh. 
Pfam
 PF00010; HLH 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS