UniProt Accession

 IMP3_HUMAN; Q9NV31; B3KQ67; Q53G10 

Genbank Protein ID

 AY050497; AL136913; AK001830; AK057531; AK223121; CH471136; BC006487; BC011745 

Genbank Nucleotide ID

 AAL06639.1; CAB66847.1; BAA91929.1; BAG51929.1; BAD96841.1; EAW99244.1; AAH06487.1; AAH11745.1 

Protein Name

 U3 small nucleolar ribonucleoprotein protein IMP3 

Protein Synonyms/Alias

 U3 snoRNP protein IMP3; BRMS2 

Gene Name

 IMP3 

Gene Synonyms/Alias

 C15orf12; MRPS4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	KLKFHEQKLLKQVDF	ubiquitination	[1]
14	FHEQKLLKQVDFLNW	ubiquitination	[1]
82	ASAALLDKLYALGLV	ubiquitination	[1, 2, 3, 4]
117	RLPTVLLKLRMAQHL	ubiquitination	[2]
165	VTWVDSSKIKRHVLE	ubiquitination	[1]
167	WVDSSKIKRHVLEYN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. 

Sequence Annotation

 DOMAIN 109 175 S4 RNA-binding.  

Keyword

 3D-structure; Complete proteome; Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:HGNC.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR022801; Ribosomal_S4/S9.
 IPR002942; S4_RNA-bd. 

Pfam

 PF01479; S4 

SMART

 SM00363; S4 

PROSITE

 PS00632; RIBOSOMAL_S4
 PS50889; S4 

PRINTS