CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001145
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 
Protein Synonyms/Alias
 Complex I-49kD; CI-49kD; NADH-ubiquinone oxidoreductase 49 kDa subunit 
Gene Name
 NDUFS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
127TEKLIEYKTYLQALPubiquitination[1]
304GIQWDLRKTQPYDVYubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 
Sequence Annotation
 METAL 326 326 Iron-sulfur (4Fe-4S) (Potential).
 METAL 332 332 Iron-sulfur (4Fe-4S) (Potential).
 METAL 347 347 Iron-sulfur (4Fe-4S) (Potential).  
Keyword
 4Fe-4S; Alternative splicing; Complete proteome; Disease mutation; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Polymorphism; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 463 AA 
Protein Sequence
MAALRALCGF RGVAAQVLRP GAGVRLPIQP SRGVRQWQPD VEWAQQFGGA VMYPSKETAH 60
WKPPPWNDVD PPKDTIVKNI TLNFGPQHPA AHGVLRLVME LSGEMVRKCD PHIGLLHRGT 120
EKLIEYKTYL QALPYFDRLD YVSMMCNEQA YSLAVEKLLN IRPPPRAQWI RVLFGEITRL 180
LNHIMAVTTH ALDLGAMTPF FWLFEEREKM FEFYERVSGA RMHAAYIRPG GVHQDLPLGL 240
MDDIYQFSKN FSLRLDELEE LLTNNRIWRN RTIDIGVVTA EEALNYGFSG VMLRGSGIQW 300
DLRKTQPYDV YDQVEFDVPV GSRGDCYDRY LCRVEEMRQS LRIIAQCLNK MPPGEIKVDD 360
AKVSPPKRAE MKTSMESLIH HFKLYTEGYQ VPPGATYTAI EAPKGEFGVY LVSDGSSRPY 420
RCKIKAPGFA HLAGLDKMSK GHMLADVVAI IGTQDIVFGE VDR 463 
Gene Ontology
 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0009055; F:electron carrier activity; NAS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0048038; F:quinone binding; IEA:InterPro.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0006979; P:response to oxidative stress; IDA:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR001135; NADH_Q_OxRdtase_suD.
 IPR014029; NADH_UbQ_OxRdtase_49kDa_CS.
 IPR022885; NDH1_su_D/H. 
Pfam
 PF00346; Complex1_49kDa 
SMART
  
PROSITE
 PS00535; COMPLEX1_49K 
PRINTS